Subtle morphological and molecular changes in normal-looking epithelium in prostates with prostatic intraepithelial neoplasia or cancer
Subtle morphological and molecular changes in normal-looking epithelium in prostates with prostatic intraepithelial neoplasia or cancer
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DOI：
10.1159/000019881
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发表时间：
1999-05-01
期刊：
影响因子：
23.4
通讯作者：
Bartels, PH
中科院分区：
文献类型：
--
作者：
Montironi, R;Hamilton, PW;Bartels, PH
背景：前列腺癌的发展需要很长一段时间。直到最近，启动该过程的事件以及伴随着向侵袭性疾病演变的发展在很大程度上是未知的。研究方法：分析和定量的方法被应用到某些个人的分子事件及其对复杂的多反馈系统的细胞代谢和调节前列腺肿瘤的影响提供见解。结果如下：前列腺上皮内瘤变（PIN）和前列腺癌（PCa）与分泌细胞核染色质的变化有关，或可能在其之前发生。这些变化可以用贝叶斯信念网络检测到，并且可以通过计算机图像分析在组织学上仍然正常的前列腺组织中进行量化。此外，正常的前列腺上皮显示出一些类似于相关的癌前病变和肿瘤病变中存在的分子变化，这种变化偶尔也存在于没有PIN和癌症的正常前列腺中。结论：正常前列腺上皮细胞的细微形态学和分子生物学改变可能是前列腺肿瘤发生发展的开始。
Background: Prostate cancer develops over an extended period of time. Until recently, the events initiating the process and the developments concomitant with the evolution towards invasive disease were largely unknown. Methods: Analytical and quantitative methods are applied to provide insights into certain individual molecular events and their effects on the complex multiple feedback system of cellular metabolism and regulation in prostate neoplasia. Results: Prostatic intraepithelial neoplasia (PIN) and prostate cancer (PCa) are associated with or possibly preceded by changes in the chromatin of secretory cell nuclei. The changes are detectable with a Bayesian belief network and quantifiable by computer image analysis in prostatic tissue that still appears histologically normal. In addition, normal-looking prostate epithelium shows some molecular changes similar to those present in the associated preneoplastic and neoplastic lesions, Such changes are also occasionally present in normal prostate glands without PIN and cancer. Conclusions:The subtle morphological and molecular changes of normal-looking epithelium might be seen as the onset of the development of prostatic neoplasia.