Single human papillomavirus 16 or 52 infection and later cytological findings in Japanese women with NILM or ASC-US.
Single human papillomavirus 16 or 52 infection and later cytological findings in Japanese women with NILM or ASC-US.
复制标题
日本 NILM 或 ASC-US 女性中的单一人乳头瘤病毒 16 或 52 感染以及随后的细胞学检查结果。
DOI：
10.1038/jhg.2014.9
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发表时间：
2014
影响因子：
3.5
通讯作者：
Masuzaki H.
中科院分区：
文献类型：
--
作者：
Abe S;Miura K;Kinoshita A;Mishima H;Miura S;Yamasaki K;Hasegawa Y;Higashijima A;Jo O;Yoshida A;Kaneuchi M;Yoshiura K;Masuzaki H.
在上皮内病变和恶性肿瘤（NILM）或意义不明的非典型鳞状细胞（ASC-US）阴性的妇女中，致癌性人乳头瘤病毒（HPV）感染与宫颈细胞学检查结果之间的关系尚不清楚。本研究在日本人群中进行了研究，以确定致癌（HPV）基因分型的临床效用。发现致癌性HPV感染后2年进行性细胞学检查结果的相对风险高于非致癌性HPV感染病例（相对风险3.827; 95%置信区间（CI）：1.282-11.422）以及阴性HPV感染病例（相对风险2.124; 95% CI：1.451-3.110）。此外，HPV-16感染病例2年后细胞学结果进展的相对风险高于HPV-52感染病例（相对风险2.094; 95%CI：1.005-3.935）。因此，在NILM或ASC-US病例中，最初的HPV-DNA基因型可能是宫颈细胞学发现后期进展的潜在预测标志。
The relationship between oncogenic human papillomavirus (HPV) infection and later cytological findings in the uterine cervix is unknown in women who were negative for intraepithelial lesion and malignancy (NILM) or atypical squamous cells of undetermined significance (ASC-US). This was investigated in this study in a Japanese population to determine the clinical utility of oncogenic (HPV) genotyping. The relative risk of progressive cytological findings 2 years after identification of oncogenic HPV infection was higher than in cases of non-oncogenic HPV infection (relative risk 3.827; 95% confidence interval (CI): 1.282–11.422), as well as in cases of negative HPV infection (relative risk 2.124; 95% CI: 1.451–3.110). Moreover, the relative risk of progression of cytological findings 2 years later in cases of HPV-16 infection was higher than in cases of HPV-52 infection (relative risk 2.094; 95% CI: 1.005–3.935). Therefore, the initial HPV-DNA genotype may be a potential predictive marker of later progression of cytological findings in the uterine cervix in cases of NILM or ASC-US.