Association between nitrite and nitrate intake and the risk of gastric cancer: Systematic review and meta-analysis
Association between nitrite and nitrate intake and the risk of gastric cancer: Systematic review and meta-analysis
复制标题
亚硝酸盐和硝酸盐摄入量与胃癌风险之间的关联：系统评价和荟萃分析
作者：
张飞雄;苗雨;阮继刚;孟淑萍
背景：研究表明，亚硝酸盐和硝酸盐的摄入量与胃癌或其相关死亡率的风险之间存在不一致的关联。对观察性研究进行荟萃分析，以评估亚硝酸盐和硝酸盐摄入量与胃癌风险的相关性。材料和方法：我们在 2018 年 11 月期间在 PubMed、EMBASE 和 Cochrane 图书馆中检索了报告胃癌效果估计及其 95% 置信区间 (CI) 的研究。使用随机效应模型汇总了纳入研究的总结结果。结果：本研究纳入了 18 项病例对照研究和 6 项前瞻性队列研究，招募了 800,321 名参与者。总结结果表明，最高（优势比[OR]，1.27；95%CI，1.03-1.55；P=0.022）或中等（OR：1.12；95%CI，1.01-1.26；P=0.037）亚硝酸盐摄入量与较高的胃癌风险相关。然而，我们注意到，高（OR，0.81；95%CI，0.68-0.97；P=0.021）或中等（OR，0.86；95%CI，0.75-0.99；P=0.036）硝酸盐摄入量与胃癌风险降低相关。当按出版年份、研究设计、国家、男性参与者的百分比、暴露评估、调整模型和研究质量分层时，这些关联有所不同。结论：高或中等亚硝酸盐摄入量与较高的胃癌风险相关，而高或中等硝酸盐摄入量与较低的胃癌风险相关。 。
Background: Studies shows inconsistent associations of nitrite and nitrate intake with the risk of gastric cancer or its associated mortality. A meta-analysis of observational studies was carried out to evaluate the correlation of nitrite and nitrate intake with the risk of gastric cancer. .Material and Methods: We searched for studies reporting effect estimates and its 95% confidence intervals (CIs) of gastric cancer in PubMed, EMBASE, and the Cochrane Library throughout November 2018. The summary results of the included studies were pooled using a random-effects model..Results: Eighteen case-control and 6 prospective cohort studies recruiting 800,321 participants were included in this study. The summary results indicated the highest (odds ratio [OR], 1.27; 95%CI, 1.03–1.55; P=0.022) or moderate (OR: 1.12; 95%CI, 1.01–1.26; P=0.037) nitrite intake were associated with a higher risk of gastric cancer. However, we noted that high (OR, 0.81; 95%CI, 0.68–0.97; P=0.021) or moderate (OR, 0.86; 95%CI, 0.75–0.99; P=0.036) nitrate intakes were associated with a reduced risk of gastric cancer. These associations differed when stratified by publication year, study design, country, the percentage of male participants, assessment of exposure, adjusted model, and study quality. .Conclusion: High or moderate nitrite intake was associated with higher risk of gastric cancer, whereas high or moderate nitrate intakes were correlated with lower risk of gastric cancer. .