BONE-LIKE APATITE COATING OF ALUMINA AND ZIRCONIA BY RF-MAGNETRON SPUTTERING
BONE-LIKE APATITE COATING OF ALUMINA AND ZIRCONIA BY RF-MAGNETRON SPUTTERING
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通过射频磁控溅射对氧化铝和氧化锆进行骨状磷灰石涂层
DOI：
10.3363/prb1992.6.0_123
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
T. Umegaki
中科院分区：
文献类型：
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作者：
K. Yamashita;T. Yagi;T. Arashi;Kouta Nakamura;T. Umegaki
我们开发了在氧化铝和氧化锆陶瓷以及钛和不锈钢等坚固材料上包覆磷灰石的技术，最近建立了在混合CO_2/Ar气氛中用反应射频磁控溅射方法形成部分碳化的羟基磷灰石类骨层的方法。这种方法的关键是使用钙磷玻璃靶材，其钙磷比比羟基磷灰石的化学计量比低得多。X射线衍射仪、EDX和FT-IR表面分析表明，CO32离子占据了磷灰石结构中PO43的晶格位置。在模拟体液中对涂层陶瓷材料表面的类骨晶体生长进行了体外实验，证实了涂层陶瓷材料的生物活性。前言尽管陶瓷羟基磷灰石(Ca5(PO4)3OH，HAP)具有无与伦比的生物活性，但仍不足以用于骨和牙齿的植入。目前已经在坚固材料上进行了羟基磷灰石涂层，以弥补这些缺点。涂层必须是骨状的，才能保持植入材料的生物活性。这种“骨状”涂层实际上是所谓的B型碳化羟基磷灰石(Ca5-x(PO4)3-y(CO3)y(O11)1-Zoz：BCHAp)的形成，其中CO32取代了晶格PO43-。射频磁控溅射是近年来发展起来的一种生物材料(1-5)，这种方法具有涂层附着力强的优点。最近，我们用钙磷比为0.60的钙磷玻璃靶材成功地在羟基磷灰石上包覆了≦，大大低于化学计量比1.67，并用CO_2和Ar混合气体反应溅射获得了前所未有的骨状涂层。本文首先报道了包覆方法和包覆层的表征，然后给出了在模拟体液中包覆层上类骨晶体生长的体外实验结果。实验：用于溅射的CP玻璃靶材是根据先前的报告(5)制备的。制备了三种不同钙磷比的靶材，并对其性能进行了研究。
We have developed the coating technology of apatite onto strong materials such as the ceramics of alumina and zirconia, and the metals of titanium and stainless steel, and recently established the method for the formation of bone-like layers of partially carbonated calcium hydroxyapatite by a reactive rf-magnetron sputtering method, which is undertaken in a mixed CO2/Ar gas ambience. Essential to this method is the use of calcium phosphate glass targets with much lower Ca/P ratios than the stoichiometric value of hydroxyapatite. It has been identified by the surface analyses of XRD, EDX, and FT-IR that CO32ions occupied the lattice positions of PO43in the apatite structure. The bioactivity of the coated ceramic materials was confirmed by the in vitro experiments of the bone-like crystal growth on their surfaces in a simulated body fluid. INTRODUCTION Despite its unparalleled bioactivity with surrounding tissues, ceramic hydroxyapatite (Ca5(PO4)3OH, HAp) is still insufficient for implant use for defective bones and teeth. HAp coatings onto strong materials have currently been undertaken in order to compensate for these shortcomings. The coated layers must be bone-like in order to sustain the bioactivity of implant materials. The "bone-like" coating is actually the forming of the so-called B-type carbonated calcium hydroxyapatite (Ca5-x(PO4)3-y(CO3)y(O11)1-zOz: BCHAp) in which CO32substitutes for the lattice PO43-. Radio frequency magnetron sputtering has recently been intensively developed for this biomaterials purpose (1-5); this method has the advantages of strong coating adhesion. We have recently succeded in the coating of HAp by the use of calcium phosphate (CP) glass target with a Ca/P of ≦0.6, much lower than the stoichiometry of 1.67, and attained the unprecedented bone-like coatings by the reactive sputtering using the mixed gas of CO2 and Ar. This paper first reports the coating method and characterizes the coated layers, then presents the results of the in vitro experiments on bone-like crystal growth on the coated layers in simulated body fluid. EXPERIMENTALPROCEMRE The CP glass targets for sputtering were prepared according to the previous report (5). Three kinds of targets with different Ca/P ratios were prepared, and the