Quality evaluation for the surveillance system of human prion diseases in China based on the data from 2010 to 2016
Quality evaluation for the surveillance system of human prion diseases in China based on the data from 2010 to 2016
复制标题
基于2010-2016年数据的我国人类朊病毒病监测体系质量评价
DOI：
10.1080/19336896.2016.1229731
复制
发表时间：
2016-01-01
期刊：
影响因子：
2.3
通讯作者：
Dong, Xiao-Ping
中科院分区：
文献类型：
--
作者：
Shi, Qi;Zhou, Wei;Dong, Xiao-Ping
我国对克雅氏病（CJD）或人朊病毒病（PrDs）的监测已进行了10年。为评价我国CJD监测系统的质量，对2010 - 2015年CJD病例的临床和流行病学资料收集、抽样、临床检查和实验室检测、随访调查等进行分析。报告单位向监测中心转诊病人的临床信息表、流行病学信息表、样本检查单和病历的获取率保持或达到很高水平，近3年接近100%。MRI、EEG、CSF 14-3-3和PRNP序列测定结果的阳性率分别为93.82%、85.23%、96.21%和94.70%。2010年和2011年对50%的病例进行了随访调查，2012年对93.39%的病例进行了随访调查，最近3年对100%的病例进行了随访调查。高的临床资料和流行病学资料获取率、高的临床检查和实验室检查开展率、高的转诊病例追踪调查率，反映了中国CJD监测系统良好的实施能力，为人类朊病毒病的识别和诊断提供了坚实的基础，保证了中国CJD监测系统的高质量。
The surveillance of CJD or human prion diseases (PrDs) has been conducted for 10y in China. To evaluate the quality of China CJD surveillance system, the collections of the clinical and epidemiological information, the sampling, the clinical examinations and laboratory tests and follow-up survey were separately analyzed based on the data from 2010 to 2015. The obtaining rates of clinical-information table, epidemiological-information table, sample inspection sheet and medical record of the referring patients from reporting units to the center of CJD surveillance maintained or reached at very high levels, being close to 100% in the past 3 y. 93.82%, 85.23%, 96.21% and 94.70% of the reported cases had the data of MRI, EEG, CSF 14-3-3 and PRNP sequencing, respectively. Follow-up surveys were conducted in about 50% cases in 2010 and 2011, 93.39% cases in 2012 and 100% cases in the last 3 y. High obtaining rates of the clinical and epidemiological data, high conducting rates of the relevant clinical examinations and laboratory tests, high performing rates of follow-up survey for every referring case reflect a good implemental capacity in China CJD surveillance system, which supplies solid basis for recognition and diagnosis of human prion diseases and guarantees good quality of China CJD surveillance system.