Impact of dietary nitrate supplementation via beetroot juice on exercising muscle vascular control in rats
Impact of dietary nitrate supplementation via beetroot juice on exercising muscle vascular control in rats
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DOI：
10.1113/jphysiol.2012.243121
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发表时间：
2013-01-01
影响因子：
5.5
通讯作者：
Poole, David C.
中科院分区：
文献类型：
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作者：
Ferguson, Scott K.;Hirai, Daniel M.;Poole, David C.
膳食硝酸盐（NO3-）补充剂，通过其还原为亚硝酸盐（NO2-）和随后转化为一氧化氮（NO）和其他活性氮中间体，降低血压和人体次极量运动的O-2成本。尽管有这些观察结果，膳食中补充NO3对运动中骨骼肌血管控制的影响仍然未知。我们测试的假设，饮食中通过甜菜根汁（BR）补充NO3-会降低平均动脉压（MAP），增加后肢肌肉血流量的运动大鼠。雄性Sprague-Dawley大鼠（3- 6个月）给予NO3-（通过甜菜根汁; 1 mmol kg（-1）天（-1），BR n = 8）或未经处理的（对照，n = 11）自来水，持续5天。在亚极量跑台运动（20 m min（-1），5%等级）期间测量MAP和后肢骨骼肌血流量和血管传导（放射性标记微球输注）。BR导致运动MAP显著降低（对照组：137+/-3，BR：127+/-4 mmHg，P
Dietary nitrate (NO3-) supplementation, via its reduction to nitrite (NO2-) and subsequent conversion to nitric oxide (NO) and other reactive nitrogen intermediates, reduces blood pressure and the O-2 cost of submaximal exercise in humans. Despite these observations, the effects of dietary NO3- supplementation on skeletal muscle vascular control during locomotory exercise remain unknown. We tested the hypotheses that dietary NO3- supplementation via beetroot juice (BR) would reduce mean arterial pressure (MAP) and increase hindlimb muscle blood flow in the exercising rat. Male Sprague-Dawley rats (3-6months) were administered either NO3- (via beetroot juice; 1 mmol kg(-1) day(-1), BR n = 8) or untreated (control, n = 11) tap water for 5 days. MAP and hindlimb skeletal muscle blood flow and vascular conductance (radiolabelled microsphere infusions) were measured during submaximal treadmill running (20 m min(-1), 5% grade). BR resulted in significantly lower exercising MAP (control: 137+/-3, BR: 127+/-4 mmHg, P