Duration of SARS-CoV-2 viremia and its correlation to mortality and inflammatory parameters in patients hospitalized for COVID-19: a cohort study.
Duration of SARS-CoV-2 viremia and its correlation to mortality and inflammatory parameters in patients hospitalized for COVID-19: a cohort study.
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DOI：
10.1016/j.diagmicrobio.2021.115595
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发表时间：
2022-03
影响因子：
2.9
通讯作者：
Ursing J
中科院分区：
文献类型：
--
作者：
Hagman K;Hedenstierna M;Rudling J;Gille-Johnson P;Hammas B;Grabbe M;Jakobsson J;Dillner J;Ursing J
入院时 SARS-CoV-2 病毒血症与高死亡风险相关。然而，有关病毒血症持续时间的纵向数据有限。因 COVID-19 住院的病毒血症患者被纳入队列。计算血清病毒清除时间以及病毒血症持续时间对死亡率的影响。包括一百二十一名病毒血症患者。中位年龄为 62 (IQR 52−71) 岁，68% 为男性。该队列的总院内死亡率为 33%。从入院到血清病毒清除的中位时间为 7 (95% CI 6−8) 天。在调整后的多项 Logistic 回归中，病毒血症持续时间显示死亡几率的相对风险比为 1.40 (95% CI 1.02−1.92)。血清病毒清除与退热和 C 反应蛋白减少同时发生。血清病毒清除的中位时间是入院后 7 天。病毒血症每增加一天，死亡率就会增加 40%。
SARS-CoV-2 viremia at admission is associated with high risk for mortality. However, longitudinal data on viremia duration are limited. Viremic patients hospitalized for COVID-19 were included in a cohort. Time to serum viral clearance and the effect of viremia duration on the odds of mortality were calculated. One hundred and twenty-one viremic patients were included. Median age was 62 (IQR 52−71) years and 68% were males. The total in-hospital mortality of the cohort was 33%. Median time from admission to serum viral clearance was 7 (95% CI 6−8) days. Duration of viremia showed a relative risk ratio of 1.40 (95% CI 1.02−1.92) for the odds of mortality in an adjusted multinomial logistic regression. Serum viral clearance coincided with defervescence and decreasing C-reactive protein. Median time to serum viral clearance was 7 days after admission. The odds of mortality increased with 40% for each additional day of viremia.
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影响因子：
8.1
作者：
Bitker L;Dhelft F;Chauvelot L;Frobert E;Folliet L;Mezidi M;Trouillet-Assant S;Belot A;Lina B;Wallet F;Richard JC
通讯作者：
Richard JC
影响因子：
15.9
作者：
Wang, Yanqun;Zhang, Lu;Zhao, Jincun
通讯作者：
Zhao, Jincun
影响因子：
3.7
作者：
Colagrossi L;Antonello M;Renica S;Merli M;Matarazzo E;Travi G;Vecchi M;Colombo J;Muscatello A;Grasselli G;Molteni SN;Scaravilli V;Cattaneo E;Fanti D;Vismara C;Bandera A;Gori A;Puoti M;Cento V;Alteri C;Perno CF
通讯作者：
Perno CF
DOI：
10.1186/s13054-020-03398-0
发表时间：
2020-12-14
期刊：
Critical care (London, England)
影响因子：
--
作者：
Bermejo-Martin JF;González-Rivera M;Almansa R;Micheloud D;Tedim AP;Domínguez-Gil M;Resino S;Martín-Fernández M;Ryan Murua P;Pérez-García F;Tamayo L;Lopez-Izquierdo R;Bustamante E;Aldecoa C;Gómez JM;Rico-Feijoo J;Orduña A;Méndez R;Fernández Natal I;Megías G;González-Estecha M;Carriedo D;Doncel C;Jorge N;Ortega A;de la Fuente A;Del Campo F;Fernández-Ratero JA;Trapiello W;González-Jiménez P;Ruiz G;Kelvin AA;Ostadgavahi AT;Oneizat R;Ruiz LM;Miguéns I;Gargallo E;Muñoz I;Pelegrin S;Martín S;García Olivares P;Cedeño JA;Ruiz Albi T;Puertas C;Berezo JÁ;Renedo G;Herrán R;Bustamante-Munguira J;Enríquez P;Cicuendez R;Blanco J;Abadia J;Gómez Barquero J;Mamolar N;Blanca-López N;Valdivia LJ;Fernández Caso B;Mantecón MÁ;Motos A;Fernandez-Barat L;Ferrer R;Barbé F;Torres A;Menéndez R;Eiros JM;Kelvin DJ
通讯作者：
Kelvin DJ
影响因子：
15.9
作者：
Li, Yijia;Schneider, Alexis M.;Li, Jonathan Z.
通讯作者：
Li, Jonathan Z.