Developmental remodeling repurposes larval neurons for sexual behaviors in adult Drosophila
Developmental remodeling repurposes larval neurons for sexual behaviors in adult Drosophila
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DOI：
10.1016/j.cub.2024.01.065
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发表时间：
2024-03-25
期刊：
影响因子：
9.2
通讯作者：
Shirangi，Troy R.
中科院分区：
文献类型：
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作者：
Diamandi，Julia A.;Duckhorn，Julia C.;Shirangi，Troy R.
果蝇的大多数幼虫神经元在变态期间被重新利用，以适应成年生活的功能，但它们对性二态行为的神经回路的贡献尚不清楚。在这里，我们确定了成年果蝇神经索中的两个中间神经元，它们控制着产卵器的排卵，这是交配后的雌性动物进行的一种求偶拒绝行为。我们发现，这两个神经元作为成熟的、性单态的中间神经元存在于幼虫的神经索中。在蛹的发育期间，它们获得了性别分化基因的表达，即双性；在雄性中，双性依赖于程序性细胞死亡；在雌性中，它们被重塑，以在雌性交配行为中发挥作用。我们的结果表明，果蝇求偶的神经回路部分是由幼虫生活中前为性共享活动的神经元重新编程而成的。
Most larval neurons inDrosophilaare repurposed during metamorphosis for functions in adult life, but their contribution to the neural circuits for sexually dimorphic behaviors is unknown. Here, we identify two interneurons in the nerve cord of adultDrosophilafemales that control ovipositor extrusion, a courtship rejection behavior performed by mated females. We show that these two neurons are present in the nerve cord of larvae as mature, sexually monomorphic interneurons. During pupal development, they acquire the expression of the sexual differentiation gene,doublesex; undergodoublesex-dependent programmed cell death in males; and are remodeled in females for functions in female mating behavior. Our results demonstrate that the neural circuits for courtship inDrosophilaare built in part using neurons that are sexually reprogrammed from former sex-shared activities in larval life.