The potential diagnosis role of TP53 mutation in advanced bladder cancer: A meta-analysis.
The potential diagnosis role of TP53 mutation in advanced bladder cancer: A meta-analysis.
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TP53 突变在晚期膀胱癌中的潜在诊断作用：荟萃分析
DOI：
10.1002/jcla.23765
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发表时间：
2021-05
影响因子：
2.7
通讯作者：
Jiang N
中科院分区：
文献类型：
--
作者：
Liao Y;Tang H;Wang M;Wang K;Wang Y;Jiang N
膀胱癌是世界上最常见的泌尿系统癌症之一，NMIBC占最近诊断的膀胱癌病例的近80%。膀胱癌的进展和复发是膀胱癌的主要问题。TP 53突变水平在高发期明显高于低发期。本Meta分析旨在通过Ta期与高期膀胱癌中TP53突变的表达来评价TP53突变的潜在诊断特征。对数据库进行了系统检索，并选择了一些相关文章。接下来，根据标准指南进行Meta分析。共纳入7个研究，按纳入标准选取677名被试。TP53基因突变与膀胱癌诊断率的增高密切相关。发现膀胱癌高分期患者TP53突变水平明显高于低分期患者，且MIBC患者TP53突变表达高于NMIBC患者。本Meta分析中未观察到显著的发表偏倚。TP53突变的表达可能是许多膀胱癌患者诊断相关的生物标志物。本Meta分析的结果进一步证明TP53突变的表达与晚期膀胱癌的诊断效率相关。TP53突变在膀胱癌高分期或MIBC中表达较高，而在膀胱癌Ta分期或NMIBC中表达较低。TP53突变的表达水平可能是晚期膀胱癌诊断的重要生物标志物。Meta分析选择过程的流程图。
Bladder cancer is one of the most common urological cancers all over the world, and NMIBC occupies almost 80% of recently diagnosed bladder cancer cases. Progress and recurrence of bladder cancer are the main problems during the disease. The level of TP53 mutation is obviously higher in the high stage than the lower. This meta‐analysis is to evaluate the potential diagnosis feature of TP53 mutation by the expression of TP53 mutation of Ta stage vs high stage in bladder cancer. A systematic search of databases was conducted, and some relevant articles were selected. Next, the meta‐analysis was carried out according to the standard guidelines. There were seven researches in which 677 participants were selected at the basis of inclusion standard. TP53 mutation was associated highly with increased diagnosis of bladder cancer. We found that the high stage of bladder cancer has obviously higher level of TP53 mutation than the lower stage, and these patients of MIBC have higher expression of TP53 mutation compared with NMIBC. No significant publication bias has been observed in this meta‐analysis. The expression of TP53 mutation might be a diagnose‐related biomarker for lots of patients with bladder cancer. The results of this meta‐analysis provided further evidences that the expression of TP53 mutation was associated with the diagnosis efficiency of advanced bladder cancer. Higher expression of TP53 mutation was observed in the high stage of bladder cancer or the MIBC, and lower expression of TP53 mutation in the Ta stage of bladder cancer or the NMIBC. The expression level of TP53 mutation was probably a critical diagnosed biomarker in advanced bladder cancer. Flowchart of selecting process for meta‐analysis.
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影响因子：
16.6
作者：
Cazier, J. -B.;Rao, S. R.;McLean, C. M.;Walker, A. L.;Wright, B. J.;Jaeger, E. E. M.;Kartsonaki, C.;Marsden, L.;Yau, C.;Camps, C.;Kaisaki, P.;Taylor, J.;Catto, J. W.;Tomlinson, I. P. M.;Kiltie, A. E.;Hamdy, F. C.
通讯作者：
Hamdy, F. C.
影响因子：
3.7
作者：
Moher D;Shamseer L;Clarke M;Ghersi D;Liberati A;Petticrew M;Shekelle P;Stewart LA;PRISMA-P Group
通讯作者：
PRISMA-P Group
影响因子：
--
作者：
Erill, N;Colomer, A;Puig, X
通讯作者：
Puig, X
影响因子：
23.4
作者：
Babjuk, Marko;Oosterlinck, Willem;Roupret, Morgan
通讯作者：
Roupret, Morgan
影响因子：
56.9
作者：
HOLLSTEIN, M;SIDRANSKY, D;HARRIS, CC
通讯作者：
HARRIS, CC