The core-inversible micelles for hydrophilic drug delivery
The core-inversible micelles for hydrophilic drug delivery
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DOI：
10.1039/c3cc43209b
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发表时间：
2013-01-01
影响因子：
4.9
通讯作者：
Luo, Juntao
中科院分区：
文献类型：
--
作者：
Huang, Wenzhe;Shi, Changying;Luo, Juntao
通过PEG（5 k）CA（8）形成独特的核可逆胶束（CIM）用于亲水性药物递送。一种抑制淀粉样蛋白原纤维的水溶性分子刚果红（CR）已被加载到CIM的亲水性核心中。在叶酸受体表达细胞系中，靶向叶酸-CIMs显著增强了亲水性CR的细胞内递送。
A unique core-inversible micelle (CIM) was formed via PEG(5k)CA(8) for hydrophilic drug delivery. An amyloid-fibril-inhibiting water-soluble molecule, congo red (CR), has been loaded into the hydrophilic core of CIMs. The targeting folate-CIMs significantly enhanced the intracellular delivery of hydrophilic CR in a folate receptor-expressing cell line.