MD-2 binds to bacterial lipopolysaccharide.
MD-2 binds to bacterial lipopolysaccharide.
复制标题
DOI：
10.1074/jbc.m105228200
复制
发表时间：
2001-10
期刊：
影响因子：
--
通讯作者：
S. Viriyakosol;Peter S. Tobias;R. Kitchens;T. Kirkland
中科院分区：
文献类型：
--
作者：
S. Viriyakosol;Peter S. Tobias;R. Kitchens;T. Kirkland
已经描述了许多LPS结合蛋白，但信号细胞的LPS受体的确切性质仍不清楚。MD-2是与Toll样受体4相关的分子，Toll样受体4已被证明是LPS的受体。我们已经在杆状病毒中产生了人MD-2，并测试了其与LPS的结合。MD-2结合LPS的脂质A区，而不需要LPS结合蛋白。这些数据表明MD-2可能作为TLR 4受体复合物的一部分结合LPS。
Many LPS binding proteins have been described, but the exact nature of the LPS receptors that signal cells remains unclear. MD-2 is a molecule that is found in association with Toll-like receptor 4, which has been shown to be a receptor for LPS. We have produced human MD-2 in baculovirus and tested it for LPS binding. MD-2 binds the lipid A region of LPS without the need for LPS binding protein. These data suggest that MD-2 may be binding LPS as part of the TLR4 receptor complex.