Intima-media thickness of the common carotid arteries is related to coronary atherosclerosis and left ventricular hypertrophy in older adults
Intima-media thickness of the common carotid arteries is related to coronary atherosclerosis and left ventricular hypertrophy in older adults
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DOI：
10.1177/000331970205300511
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发表时间：
2002-09-01
期刊：
影响因子：
2.8
通讯作者：
van der Cammen, TJM
中科院分区：
文献类型：
--
作者：
Raso, FM;van Popele, NM;van der Cammen, TJM
颈总动脉内膜-中膜厚度（IMT）增加与全身性动脉粥样硬化以及未来心肌梗死和脑血管疾病的风险增加有关。IMT与冠状动脉疾病（CAD）之间的关系已被证实，但关于IMT增加与CAD程度之间的关系却存在争议。颈动脉粥样硬化与心脏重构之间的关系也有报道。目前尚不清楚颈总动脉IMT升高是否与老年人心血管疾病的流行有关。本研究包括70例患者，其中37例患有CAD， 33例年龄和性别匹配的无CAD。所有患者均接受了基线临床检查、颈动脉b超和超声心动图检查。作者评估了IMT增加与CAD的存在和程度以及左心室肥厚（LVH）的存在之间的可能关联，与非CAD患者相比，CAD患者的IMT显著增加。在调整了年龄、性别、高血压、高胆固醇血症、糖尿病和吸烟习惯等因素后，发现IMT随冠状血管数量的增加而增加
Increased intima-media thickness (IMT) of the common carotid arteries is related to generalized atherosclerosis and increased risk of future myocardial infarction and cerebrovascular disease. An association between IMT and the presence of coronary artery disease (CAD) has been documented, but controversial data have been found about the relation between increased IMT and the extent of CAD, An association between carotid atherosclerosis and cardiac remodeling has also been reported. It is still unclear whether increased IMT of the common carotid arteries might be associated with prevalent cardiovascular disease in older adults. This study included 70 patients, 37 with CAD and 33 matched for age and gender without CAD. All patients underwent a baseline clinical examination, B-mode ultrasound of the carotid arteries, and echocardiography. The authors evaluated the possible association between increased IMT with the presence and extent of CAD and the presence of left ventricular hypertrophy (LVH), The patients with CAD had significantly increased IMT compared to patients without CAD. IMT was found to increase with the number of coronary vessels affected, after adjustment for age, gender, hypertension, hypercholesterolemia, diabetes mellitus, and smoking habits, The test for trend was highly significant (p