Precision Medicine Approaches to Cardiac Arrhythmias
Precision Medicine Approaches to Cardiac Arrhythmias
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DOI：
10.1016/j.jacc.2021.03.325
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发表时间：
2021-05-17
影响因子：
24
通讯作者：
Kovacic, Jason C.
中科院分区：
文献类型：
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作者：
Giudicessi, John R.;Ackerman, Michael J.;Kovacic, Jason C.
在本专题研讨会系列的前三篇论文中，回顾了精准医学的基础和关键概念，然后重点介绍了血管疾病和心肌病背景下的精准医学。在剩下的两篇论文中，我们将重点关注心律失常背景下的精准医学。具体来说，在这第四篇论文中，我们关注长QT综合征、Brugada综合征和心房颤动。最后（第五篇）论文将讨论儿茶酚胺能多形性室性心动过速。这些心律失常代表了从常见到相对罕见的一系列疾病，具有非常不同的遗传和环境致病因素，并且具有不同的临床表现，如果不治疗，从几乎没有后果到儿童或青少年的致命。因此，针对这些心律失常的新兴精准医学方法差异很大，但几个共同的主题包括增加基因检测的使用，避免触发因素，以及个性化风险分层来指导心律失常特异性治疗的使用。[J] journal of Cardiology; 2011;77:2573-91) (c)美国心脏病学会基金会2021。
In the initial 3 papers in this Focus Seminar series, the fundamentals and key concepts of precision medicine were reviewed, followed by a focus on precision medicine in the context of vascular disease and cardiomyopathy. For the remaining 2 papers, we focus on precision medicine in the context of arrhythmias. Specifically, in this fourth paper we focus on long QT syndrome, Brugada syndrome, and atrial fibrillation. The final (fifth) paper will deal with catecholaminergic polymorphic ventricular tachycardia. These arrhythmias represent a spectrum of disease ranging from common to relatively rare, with very different genetic and environmental causative factors, and with differing clinical manifestations that range from almost no consequences to lethality in childhood or adolescence if untreated. Accordingly, the emerging precision medicine approaches to these arrhythmias vary significantly, but several common themes include increased use of genetic testing, avoidance of triggers, and personalized risk stratification to guide the use of arrhythmiaspecific therapies. (J Am Coll Cardiol 2021;77:2573-91) (c) 2021 by the American College of Cardiology Foundation.