Distribution of mammographic density and its influential factors among Chinese women
Distribution of mammographic density and its influential factors among Chinese women
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中国女性乳腺X线密度分布及其影响因素
DOI：
10.1093/ije/dyu042
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发表时间：
2014-08-01
影响因子：
7.7
通讯作者：
Chen, Kexin
中科院分区：
文献类型：
--
作者：
Dai, Hongji;Yan, Ye;Chen, Kexin
背景：中国女性乳腺摄影密度（MD）尚未进行系统研究。乳腺癌筛查计划提供了详细的信息MD在大量的无症状women.Methods：在多模态独立筛查试验（MIST），我们估计MD及其影响因素之间的关联，采用Logistic回归，调整年龄，体重指数（BMI）和研究领域。中国和其他种族群体之间的差异，就MD也探讨了调整年龄和BMI.Results：共28 388名妇女，年龄在45至65岁，谁已被筛选的乳房X线摄影，参加了这项研究。其中，49.2%被归类为致密乳房（BI-RADS密度3和4），50.8%被归类为脂肪乳房（BI-RADS密度1和2）。绝经后状态[比值比（OR）= 0.66; 95%置信区间（CI）：0.62-0.70]和较高的活产数（OR = 0.56; 95%CI：0.46-0.68）与MD呈负相关，而既往良性乳腺疾病（OR = 1.48; 95% CI：1.40-1.56）和较大的初产年龄（OR = 1.17; 95% CI：1.08-1.27）与MD呈正相关。与来自乳腺癌监测联盟的数据相比，我们发现，在年龄较大的人群（>= 50岁）中，MIST中的女性比美国人（来自乳腺癌监测联盟）更容易有脂肪乳房，但在年龄较小的人群中更容易有致密乳房（
Background: Mammographic density (MD) has not been systematically investigated among Chinese women. Breast cancer screening programmes provided detailed information on MD in a large number of asymptomatic women.Methods: In the Multi-modality Independent Screening Trial (MIST), we estimated the association between MD and its influential factors using logistic regression, adjusting for age, body mass index (BMI) and study area. Differences between Chinese and other ethnic groups with respect to MD were also explored with adjustment for age and BMI.Results: A total of 28 388 women aged 45 to 65 years, who had been screened by mammography, were enrolled in the study. Of these, 49.2% were categorized as having dense breasts (BI-RADS density 3 and 4) and 50.8% as fatty breasts (BI-RADS density 1 and 2). Postmenopausal status [odds ratio (OR) = 0.66; 95% confidence interval (CI): 0.62-0.70] and higher number of live births (OR = 0.56; 95% CI: 0.46-0.68) were inversely associated with MD, whereas prior benign breast disease (OR = 1.48; 95% CI: 1.40-1.56) and later age at first birth (OR = 1.17; 95% CI: 1.08-1.27) were positively associated with MD. In comparison with the data from the Breast Cancer Surveillance Consortium, we found that women in MIST were more likely to have fatty breasts than Americans (from the Breast Cancer Surveillance Consortium) in the older age group (>= 50 years) but more likely to have dense breasts in the younger age group (