CD95-induced apoptosis of lymphocytes in an immune privileged site induces immunological tolerance
CD95-induced apoptosis of lymphocytes in an immune privileged site induces immunological tolerance
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DOI：
10.1016/s1074-7613(00)80305-2
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发表时间：
1996-07-01
期刊：
影响因子：
32.4
通讯作者：
Ferguson, TA
中科院分区：
文献类型：
--
作者：
Griffith, TS;Yu, XH;Ferguson, TA
我们研究了抗原注射到眼前房后细胞死亡和耐受诱导之间的关系。我们的数据表明，当炎症细胞发生细胞凋亡后感染HSV-1，耐受性的病毒观察。相反，当由于Fas或FasL缺陷而不存在细胞死亡时，未观察到免疫耐受。进一步的研究表明，细胞死亡和耐受需要淋巴细胞Fas（+）和眼睛FasL（+）。此外，我们表明，虽然Fas/FasL介导的细胞凋亡发生在眼睛，这是凋亡性细胞死亡，是关键的耐受诱导。我们的研究结果进一步证明了免疫赦免不是一个涉及物理屏障的被动过程，而是一个主动过程，它采用了一种重要的自然机制来诱导细胞死亡和免疫耐受。
We examined the relationship between cell death and tolerance induction following antigen injection into the anterior chamber of the eye. Our data show that when inflammatory cells undergo apoptosis following infection with HSV-1, tolerance to the virus was observed. In contrast, when cell death was absent due to defects in Fas or FasL, immune tolerance was not observed. Further studies revealed that cell death and tolerance required that the lymphoid cells be Fas(+) and the eye be FasL(+). Additionally, we show that while Fas/FasL-mediated apoptosis occurred in the eye, it was apoptotic cell death that was critical for tolerance induction. Our results further demonstrate immune privilege is not a passive process involving physical barriers, but is an active process that employs an important natural mechanism to induce cell death and immune tolerance.