TOPOGRAPHICAL PROJECTIONS FROM THE THALAMUS, SUBTHALAMIC NUCLEUS AND PEDUNCULOPONTINE TEGMENTAL NUCLEUS TO THE STRIATUM IN THE JAPANESE MONKEY, MACACA-FUSCATA
TOPOGRAPHICAL PROJECTIONS FROM THE THALAMUS, SUBTHALAMIC NUCLEUS AND PEDUNCULOPONTINE TEGMENTAL NUCLEUS TO THE STRIATUM IN THE JAPANESE MONKEY, MACACA-FUSCATA
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DOI：
10.1016/0006-8993(90)90339-d
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发表时间：
1990-12-24
期刊：
影响因子：
2.9
通讯作者：
MIZUNO, N
中科院分区：
文献类型：
--
作者：
NAKANO, K;HASEGAWA, Y;MIZUNO, N
用WGA-HRP逆行轴突运输技术研究了日本猕猴（Macacafuscata）丘脑、丘脑底核（Subthalamic nucleus，简称丘脑底核）和脚桥被盖核（Pedunculopontine tegmental nucleus，简称PPN）向纹状体的定位投射。 尾状核（CN）或壳核（Put）头部注射WGA-HRP后，标记的丘脑神经元胞体主要分布于腹前核（VA）-腹外侧核（VL）复合体和中央中核（CM）-束旁核（Pf）复合体，此外还分布于室旁核、纹旁核、菱形核、连合核、中央背侧核、中央外侧核、中央旁核、和中央核。 结果表明，VA的主部（VApc）主要投射到CN，同时也投射到Put，VA的大细胞部（VAmc）或VL的口部（VLo）分别选择性地投射到CN或Put。 CM向Put的中、尾部投射，Pf向CN和Put的吻部投射。 CM的背内侧部、腹内侧部和外侧部分别投射到Put的背外侧部、腹内侧部和中间部，Pf的内侧部和外侧部分别投射到CN头的内侧部和外侧部。 证实了纹状体和PPN的直接投射。丘脑底纹状体投射呈中外侧型。 PPN被证明是项目双侧纹状体同侧优势。
Topographical projections from the thalamus, subthalamic nucleus (STN) and pedunculopontine tegmental nucleus (PPN) to the striatum were examined in the Japanese monkey (Macaca fuscata) by using the retrograde axonal transport technique of WGA-HRP (wheat germ agglutinin-conjugated horseradish peroxidase). After WGA-HRP injection in the head of the caudate nucleus (CN) or putamen (Put), labeled neuronal cell bodies in the thalamus were distributed mainly in the nucleus ventralis anterior (VA)-nucleus ventralis lateralis (VL) complex and the nucleus centrum medianum (CM)-nucleus parafascicularis (Pf) complex, and additionally in the paraventricular, parataenial, rhomboid, reuniens, centrodorsal, centrolateral, paracentral, and centromedial nuclei. The data indicated that the pars principalis of VA (VApc) projected mainly to CN and additionally to Put, and that the pars magnocellularis of VA (VAmc) or pars oralis of VL (VLo) projected selectively to CN or Put, respectively. It was also indicated that CM projected to the middle and caudal parts of Put, while Pf projected to CN and the rostral part of the Put. The data further indicated that the dorsomedial, ventromedial, or lateral part of CM projected respectively to the dorsolateral, ventromedial, or intermediate part of Put, and that the medial or lateral part of Pf projected respectively to the medial or lateral part of the head of CN. Direct projections from STN and PPN to the striatum were confirmed. The subthalamostriatal projections showed a mediolateral topography. The PPN was shown to project bilaterally to the striatum with an ipsilateral predominance.