Hox proteins meet more partners

Hox proteins meet more partners
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DOI:
10.1016/s0959-437x(98)80113-5
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发表时间:
1998-08-01
影响因子:
4
通讯作者:
Affolter, M
Affolter, M
中科院分区:
生物学2区
文献类型:
--
作者:
Mann, RS;Affolter, M

文献摘要

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Hox 基因是一组包含同源盒的基因,在动物发育中发挥着核心作用。最近的遗传和分子数据表明 Hox 蛋白与预先存在的同源域蛋白复合物相互作用。这些复合物可能有助于调节 Hox 活性和 Hox 特异性,并帮助细胞解释发育过程中的信号级联。
The Hox genes are clustered sets of homeobox-containing genes that play a central role in animal development. Recent genetic and molecular data suggest that Hox proteins interact with pre-existing homeodomain protein complexes. These complexes may help to regulate Hox activity and Hox specificity and help cells to interpret signaling cascades during development.