The peripheral vascular response to exercise is impaired in patients with risk factors for coronary artery disease
The peripheral vascular response to exercise is impaired in patients with risk factors for coronary artery disease
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DOI：
10.1159/000047358
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发表时间：
2001-01-01
期刊：
影响因子：
1.9
通讯作者：
Goor, D
中科院分区：
文献类型：
--
作者：
Chenzbraun, A;Levin, G;Goor, D
背景：在具有冠状动脉疾病（CAD）危险因素的个体中已经描述了异常的冠状动脉和肱动脉反应。外周动脉张力测定（PAT）是一种新开发的数字体积描记技术，用于评估健康对照者和有危险因素的个体对运动的外周血管反应。方法和结果：在 Bruce 协议运动测试期间，对 30 名具有 CAD 危险因素的受试者和 30 名健康个体进行了连续手指 PAT。与基线相比，受试者峰值运动时的 PAT 波振幅下降，但对照组增加：分别为 83 +/- 28% 与 114 +/- 40%，p < 0.01。结论：在具有动脉粥样硬化危险因素的个体中发现了不同的全身血管对运动的反应模式。由于这些患者的血管行为可能与内皮功能障碍有关，因此外周动脉张力测定可能可以作为一种简单、易于使用的技术来评估内皮功能。版权所有 (C) 2001 S. Karger AG，巴塞尔。
Background: Abnormal coronary and brachial artery responses have been described in individuals with risk factors for coronary artery disease (CAD). Peripheral arterial tonometry (PAT), a newly developed digital plethysmographic technique was used to assess peripheral vascular response to exercise in healthy controls and individuals with risk factors. Methods and Results: Continuous finger PAT during Bruce protocol exercise test was performed in 30 subjects with risk factors for CAD and 30 healthy individuals. Compared with baseline, the PAT wave amplitude at peak exercise decreased in the subjects but increased in the controls: 83 +/- 28% vs. 114 +/- 40% respectively, p < 0.01. Conclusions: A different pattern of systemic vascular response to exercise was found in individuals with risk factors for atherosclerosis. Since the vascular behavior in these patients is probably related to endothelial dysfunction, it may be that peripheral arterial tonometry can be used as a simple, readily available technique to assess endothelial function. Copyright (C) 2001 S. Karger AG, Basel.