Ceramide-1-phosphate in phagocytosis and calcium homeostasis.
Ceramide-1-phosphate in phagocytosis and calcium homeostasis.
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DOI：
10.1007/978-1-4419-6741-1_9
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发表时间：
2010
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鞘磷脂是重要信号分子的可靠来源。例如，神经酰胺(Ceramide，Cer)被描述为一种强有力的细胞生长抑制和细胞凋亡诱导剂。相反，1-磷酸神经酰胺(C1P)已被报道具有促有丝分裂和抑制细胞凋亡的特性。我们对C1P在调节DNA合成、炎症、膜融合和细胞内钙增加中的不同生物学作用的了解迅速扩大。C1P是神经酰胺在神经酰胺酶(Cerk)催化下磷酸化形成的一种生物活性神经鞘糖脂。本章特别关注C1P在吞噬和钙稳态中的作用。研究C1P在吞噬过程中的代谢，可能有助于更好地理解其在信号转导中的作用。潜在地，抑制CEK和C1P的形成可能成为治疗炎症的靶点。
Sphingolipids are well established sources of important signaling molecules. For example, ceramide (Cer) has been described as a potent inhibitor of cell growth and inducer of apoptosis. In contrast, ceramide 1-phosphate (C1P) has been reported to have mitogenic properties and to inhibit apoptosis. Our understanding of the distinct biological roles of C1P in the regulation of DNA synthesis, inflammation, membrane fusion, and intracellular Ca2+ increase has rapidly expanded. C1P is a bioactive sphingolipid formed by the phosphorylation of ceramide catalyzed by ceramide kinase (CERK). This chapter specifically focuses on the role of C1P in phagocytosis and Ca2+ homeostasis. Studies of the metabolism of C1P during phagocytosis, may lead to a better understanding of its role in signaling. Potentially, the inhibition of CERK and C1P formation may be a therapeutic target for inflammation.