Ontogeny of the levels of biogenic amines in various parts of the brain and in peripheral tissues in normal and protein malnourished rats
Ontogeny of the levels of biogenic amines in various parts of the brain and in peripheral tissues in normal and protein malnourished rats
复制标题
正常和蛋白质营养不良大鼠大脑各部位和外周组织生物胺水平的个体发育
DOI：
10.1016/0014-4886(75)90214-9
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发表时间：
1975
影响因子：
5.3
通讯作者：
O. Resnick
中科院分区：
文献类型：
--
作者：
Warren C. Stern;Maravene Miller;W. B. Forbes;P. Morgane;O. Resnick
在正常和蛋白质营养不良的大鼠从出生到300天的年龄，在大脑区域和外周组织中的5-羟色胺，5-羟基吲哚乙酸，和去甲肾上腺素的个体发育进行了检查。营养不良的大鼠在受孕前5周开始接受低蛋白饮食，出生时脑和外周组织中生物胺和5-羟基吲哚乙酸水平显着升高。据报道，这是蛋白质营养不良影响大脑主要生化指标的最早年龄之一。在营养不良的大鼠中，5-羟色胺和5-羟基乙酸的脑浓度在年龄较大时（长达300天）仍然升高，最大的影响（增加高达200%）发生在端脑下区域。脑吲哚水平的这些变化可能代表吲哚胺代谢的一般代谢改变，因为在心脏、肺和胃中也观察到吲哚浓度升高。在大多数年龄段，营养不良大鼠脑去甲肾上腺素水平的增加不如吲哚明显。此外，未观察到外周组织中去甲肾上腺素浓度增加。就去甲肾上腺素浓度而言，大脑似乎比外周组织对蛋白质营养不良的损害更敏感。目前的结果表明，饲养大鼠的饮食蛋白质低，但在所有其他方面足够，显着提高脑胺含量在大多数年龄从出生到300天的年龄。
The ontogenetic development of serotonin, 5-hydroxyindoleacetic acid, and norepinephrine in brain regions and in peripheral tissues was examined in normal and protein malnourished rats from birth to age 300 days. The malnourished rats, which received a diet low in protein starting 5 weeks prior to conception, showed significantly elevated brain and peripheral tissue levels of the biogenic amines and 5-hydroxyindoleacetic acid at birth. This is one of the earliest ages at which protein malnutrition has been reported to affect a major biochemical measure in the brain. In malnourished rats, brain concentrations of serotonin and 5-hydroxydoleacetic acid remained elevated at older ages, up to 300 days, with the largest effects (up to 200% increase) occurring in subtelencephalic brain regions. These changes in brain indole levels probably represent a general metabolic alteration of indoleamine metabolism since elevated indole concentrations were also observed in the heart, lung, and stomach. At most ages the increase in brain norepinephrine levels in malnourished rats was less pronounced than for the indoles. Also, no increase in norepinephrine concentration in the peripheral tissues were observed. With respect to norepinephrine concentrations, the brain appears to be more sensitive to the insult of protein malnutrition than do peripheral tissues. The present results demonstrate that rearing rats on a diet low in protein, but adequate in all other respects, significantly elevates the brain amine content at most ages from birth through 300 days of age.