Inflammatory networks and immune surveillance of pancreatic carcinoma.
Inflammatory networks and immune surveillance of pancreatic carcinoma.
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DOI：
10.1016/j.coi.2013.01.006
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发表时间：
2013-04
影响因子：
7
通讯作者：
Bayne LJ
中科院分区：
文献类型：
--
作者：
Vonderheide RH;Bayne LJ
癌症相关炎症在抑制抗肿瘤免疫中起着重要作用，特别是在胰腺导管腺癌（PDA）中，免疫抑制白细胞大量浸润到肿瘤基质中是肿瘤发生的早期和一致的事件。这种病理生理与许多其他实体肿瘤形成对比，其中效应T细胞的浸润通常很突出，与改善的临床结果相关，并且在机制上有助于肿瘤免疫编辑，最终可以介导免疫逃逸。在PDA中，越来越多的证据表明ras癌基因驱动炎症程序，在肿瘤微环境中建立免疫特权。事实上，PDA细胞可能对T细胞杀伤保持固有的敏感性，因为它们在体内从未暴露于T细胞的选择压力下。为了支持这一假设，最近的研究表明，PDA微环境中脱轨的免疫抑制途径，如肿瘤来源的GM-CSF，促进了t细胞介导的肿瘤排斥反应。这些发现对开发胰腺癌的新型联合免疫疗法具有重要意义。
Cancer-associated inflammation plays an important role in restraining anti-tumor immunity, particularly in pancreatic ductal adenocarcinoma (PDA) for which a massive infiltration of immunosuppressive leukocytes into the tumor stroma is an early and consistent event in oncogenesis. This pathophysiology is in contrast to many other solid tumors for which infiltration of effector T cells is often prominent, associated with improved clinical outcomes, and mechanistically contributes to tumor immunoediting that ultimately can mediate immune escape. In PDA, increasing evidence suggests that the ras oncogene drives an inflammatory program that establishes immune privilege in the tumor microenvironment. Indeed, PDA cells might remain intrinsically sensitive to T cell killing because they have never been exposed to T cell selective pressure in vivo. In support of this hypothesis, recent studies demonstrate that derailing immune suppressive pathways in the PDA microenvironment, such as tumor derived GM-CSF, facilitates T-cell mediated tumor rejection. These findings carry major implications for the development of novel, combination immunotherapies for pancreatic cancer.
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影响因子：
64.8
作者：
DuPage, Michel;Mazumdar, Claire;Schmidt, Leah M.;Cheung, Ann F.;Jacks, Tyler
通讯作者：
Jacks, Tyler
DOI：
10.1084/jem.20101876
发表时间：
2011-03-14
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
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通讯作者：
Protti MP
影响因子：
11.2
作者：
Bunt, Stephanie K.;Yang, Linglin;Ostrand-Rosenberg, Suzanne
通讯作者：
Ostrand-Rosenberg, Suzanne
影响因子：
4.4
作者：
Bronte, V;Serafini, P;Zanovello, P
通讯作者：
Zanovello, P
影响因子：
50.3
作者：
Hingorani, SR;Wang, LF;Tuveson, DA
通讯作者：
Tuveson, DA