Contributions of Primate Prefrontal and Posterior Parietal Cortices to Length and Numerosity Representation
Contributions of Primate Prefrontal and Posterior Parietal Cortices to Length and Numerosity Representation
复制标题
DOI：
10.1152/jn.90713.2008
复制
发表时间：
2009-06-01
影响因子：
2.5
通讯作者：
Nieder, Andreas
中科院分区：
文献类型：
--
作者：
Tudusciuc, Oana;Nieder, Andreas
张建平。灵长类动物前额叶和顶叶后皮层对长度和数量表征的贡献。中国生物医学工程学报（英文版），2009。首次发表于2009年3月25日；doi: 10.1152 / jn.90713.2008。理解和操纵数量的能力保证了动物和人类的生存。灵长类动物的额顶叶网络与表现抽象数量的认知能力以及其他能力有关。然而，前额叶和顶叶区域各自的作用，以及连续量（而不是离散量）在该网络中的表现方式，都是未知的。我们通过同时分析两只猕猴在进行延迟匹配-样本任务时，前额叶皮层（PFC）和顶叶内沟（IPS）底部的单单元活动来研究这一问题。在这两个区域，我们发现解剖学上混杂的神经元编码长度，数量，或两种类型的数量。尽管不同的神经元组对这些数量进行编码，但长度和数量的表示在IPS和pfc中是相似的。长度和数量都是通过调节函数在首选数量上达到峰值来编码的，从而支持连续和离散数量的标记线编码。通过比较顶叶和额叶区域的反应特征，我们发现在早期的采样阶段，代表每种数量类型的IPS神经元所占的比例更大，而且IPS神经元对数量的反应潜伏期更短。此外，IPS神经元在采样阶段比PFC神经元更好地区分数量，这是由接收器工作特征面积量化的。在记忆期，PFC和IPS神经元放电特性具有可比性。这些单细胞结果与人类的功能成像数据很好地一致，并支持连续和离散量的表征共享额顶叶基底的概念，IPS神经元构成了处理层次的假定入口阶段。
Tudusciuc O, Nieder A. Contributions of primate prefrontal and posterior parietal cortices to length and numerosity representation. J Neurophysiol 101: 2984-2994, 2009. First published March 25, 2009; doi: 10.1152/jn.90713.2008. The ability to understand and manipulate quantities ensures the survival of animals and humans alike. The frontoparietal network in primates has been implicated in representing, along with other cognitive abilities, abstract quantity. The respective roles of the prefrontal and parietal areas and the way continuous quantities, as opposed to discrete ones, are represented in this network, however, are unknown. We investigated this issue by simultaneously analyzing recorded single-unit activity in the prefrontal cortex (PFC) and the fundus of the intraparietal sulcus (IPS) of two macaque monkeys while they were engaged in delayed match-to-sample tasks discriminating line length and numerosity. In both areas, we found anatomically intermingled neurons encoding either length, numerosity, or both types of quantities. Even though different sets of neurons coded these quantities, the representation of length and numerosity was similar within the IPS and PFC. Both length and numerosity were coded by tuning functions peaking at the preferred quantity, thus supporting a labeled-line code for continuous and discrete quantity. A comparison of the response characteristics between parietal and frontal areas revealed a larger proportion of IPS neurons representing each quantity type in the early sample phase, in addition to shorter response latencies to quantity for IPS neurons. Moreover, IPS neurons discriminated quantities during the sample phase better than PFC neurons, as quantified by the receiver operating characteristic area. In the memory period, the discharge properties of PFC and IPS neurons were comparable. These single-cell results are in good agreement with functional imaging data from humans and support the notion that representations of continuous and discrete quantities share a frontoparietal substrate, with IPS neurons constituting the putative entry stage of the processing hierarchy.