Nanometer Level Resolving Near Field Optical Microscope under Optical Feedback in the Observation of a Single-String Deoxyribo Nucleic Acid
Nanometer Level Resolving Near Field Optical Microscope under Optical Feedback in the Observation of a Single-String Deoxyribo Nucleic Acid
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光学反馈下的纳米级分辨近场光学显微镜观察单链脱氧核糖核酸
DOI：
10.1143/jjap.38.6713
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Motoichi Ohtsu Motoichi Ohtsu
中科院分区：
文献类型：
--
作者：
Uma Maheswari Rajagopalan;Shuji Mononobe Yoshimoto;Motoichi Ohtsu Motoichi Ohtsu
利用收集模式近场光学显微镜（NOM），以光学近场强度作为反馈信号，在定距模式下对单链脱氧核糖核酸（DNA）进行了观察。观察到的最窄弦的宽度约为4 nm。据我们所知，这不仅是一个成功的光学观察单字符串DNA的纯光学手段，而且在这样的高分辨率的能力。这种高分辨率主要归因于在样品和探针的制备过程中特别小心以避免不必要的散射光。探头有效地拾取散射近场的高空间频率分量，同时有效地排除低空间频率分量。
We present the observation results of a single string deoxyribo nucleic acid (DNA) obtained by a collection mode near field optical microscope (NOM) operated under constant distance mode with the optical near field intensity as the feedback signal. The observed width of the narrowest string is around 4 nm. To our knowledge, this is not only the successful optical observation of a single string DNA by purely optical means but also under such high resolving capability. This high resolution is mainly attributed to the special care taken during the preparation of the sample and of the probe to avoid unwanted scattered light. The probe efficiently picks up the high spatial frequency component of the scattered near field and simultaneously rejects out effectively the lower spatial frequency components.