Left ventricular hypertrophy and abnormal ventricular geometry in children and adolescents with obstructive sleep apnea
Left ventricular hypertrophy and abnormal ventricular geometry in children and adolescents with obstructive sleep apnea
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DOI：
10.1164/rccm.2105118
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发表时间：
2002-05-15
影响因子：
24.7
通讯作者：
Daniels, SR
中科院分区：
文献类型：
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作者：
Amin, RS;Kimball, TR;Daniels, SR
阻塞性睡眠呼吸暂停（OSA）已被证明是成人心血管疾病的独立危险因素。然而，在儿童中研究OSA的心血管后果的程度存在严重的局限性。为探讨阻塞性睡眠呼吸暂停（OSA）患儿的超声心动图改变，对28例OSA患儿和19例原发性打鼾（PS）患儿的右、左心室（RV、LV）内径、左心室质量指数和几何形态进行了测量。研究表明，OSA组的左室质量指数和相对壁厚大于PS组（分别为p=0.012和p BLD lt; 0.0001）。呼吸暂停低通气指数大于10/小时与RV尺寸大于第95百分位数（优势比，6.7; 95%置信区间，1.4-32）和LV质量指数大于第95百分位数（优势比，11.2;置信区间，1.9-64）显著相关。PS患儿中15%的左室几何结构异常，而OSA患儿中39%的左室几何结构异常。我们的结论是，儿童阻塞性睡眠呼吸暂停与左室质量增加。
Obstructive sleep apnea (OSA) has been shown to be an independent risk factor for cardiovascular disease in adults. However, there are severe limitations in the extent to which the cardiovascular consequences of OSA are being studied in children. To investigate the echocardiographic changes in children with OSA, right and left ventricular (RV, LV) dimensions and LV mass index and geometry were measured in 28 children with OSA and 19 children with primary snoring (PS). The study showed that LV mass index and relative wall thickness were greater in the OSA group compared with those with PS (p=0.012 and p BLDlt; 0.0001, respectively). An apnea-hypopnea index of more than 10 per hour was significantly associated with RV dimension above the 95th percentile (odds ratios, 6.7; 95% confidence interval, 1.4-32) and LV mass index above the 95th percentile (odds ratios, 11.2; confidence interval, 1.9-64). Abnormality of LV geometry was present in 15% of children with PS compared with 39% of children with OSA. We conclude that OSA in children is associated with increased LV mass.