Radioiodine secretion in tears.
Radioiodine secretion in tears.
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眼泪中放射性碘的分泌。
DOI：
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发表时间：
1998
影响因子：
9.3
通讯作者：
Fawzia Bajaafar
中科院分区：
文献类型：
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作者：
S. Bakheet;M. Hammami;A. Hemidan;J. Powe;Fawzia Bajaafar
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根据之前的闪烁照相观察，怀疑泪液分泌放射性碘。我们对接受甲状腺素治疗的甲状腺消融患者的泪液中放射性碘的分泌量进行了半定量，并用人工眼对患者进行了测定。
方法
口服 555 MBq (15 mCi) 123I 后，使用 Schirmer 试纸在 24 小时内收集了 12 个泪液样本。摄入放射性碘 27 小时后，在孔计数器中测定每个样品的放射性，并针对衰减和计数效率进行校正。
结果
放射性碘摄入后 15 分钟和长达 24 小时可检测到放射性，并在约 60 分钟时达到峰值（215 Bq/μl 或给药剂量的 39 x 10(6)%/μl。考虑到 1μl/min 的泪液流速，前 4 小时内分泌的总放射性估计为 56 kBq，约占给药剂量的 0.01%。
结论
大量摄入的放射性碘可以通过眼泪分泌。高剂量131I治疗后泪腺的潜在损伤值得进一步研究。
UNLABELLED
Lacrimal secretion of radioiodine has been suspected from previous scintigraphic observations. We semiquantitated radioiodine secretion in the tears of a thyroid-ablated patient with an artificial eye while the patient was on thyroxine treatment.
METHODS
After an oral dose of 555 MBq (15 mCi) 123I, 12 tear samples were collected over 24 hr by using Schirmer papers. Radioactivity in each sample was determined in a well counter 27 hr after radioiodine ingestion and was corrected for decay and counting efficiency.
RESULTS
Radioactivity was detectable at 15 min and at up to 24 hr after radioiodine ingestion and peaked at around 60 min (215 Bq/microl or 39 x 10(6)% of the administered dose/microl. Considering a tear-flow rate of 1 microl/min, the total radioactivity secreted in the first 4 hr was estimated to be 56 kBq, representing about 0.01% of the administered dose.
CONCLUSION
An appreciable amount of ingested radioiodine could be secreted in tears. The potential damage of the lacrimal gland after high doses of 131I treatment deserves further study.