Effects of age on the physiological and mechanical characteristics of human femoropopliteal arteries
Effects of age on the physiological and mechanical characteristics of human femoropopliteal arteries
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DOI：
10.1016/j.actbio.2014.09.050
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发表时间：
2015-01-01
影响因子：
9.7
通讯作者：
MacTaggart, Jason N.
中科院分区：
文献类型：
--
作者：
Kamenskiy, Alexey V.;Pipinos, Iraklis I.;MacTaggart, Jason N.
手术和介入治疗外周动脉疾病（PAD）是臭名昭著的高失败率。动脉和修复材料之间的相互作用起着重要作用，但目前还没有描述人股腘动脉生理和力学特性的全面数据。从70名人类受试者（13-79岁）中获得新鲜股腘动脉，并测量原位动脉与切除动脉的长度。测定股浅动脉近端、腘动脉近端和腘动脉远端圆周和纵向开角。采用多比平面双轴拉伸法评估其力学性能，并利用实验数据计算其生理应力和拉伸、原位轴向力和各向异性。采用verhoefff - van gieson染色的动脉轴、横切片进行组织学分析。大多数试件表现出非线性变形，纵向比周向更柔顺。原位轴向预拉伸每10年寿命减少0.088。原位轴向力和轴向应力随年龄增大而减小，但周向生理应力保持不变。45岁后，生理周向拉伸减少55 ~ 75%。组织学显示外弹性层增厚，纵向定向弹性蛋白，在较小的年轻动脉中密度更大。轴向弹性蛋白可能调节轴向预拉伸，以帮助适应运动过程中动脉壁所需的复杂变形。由于年龄、循环机械应力和动脉粥样硬化性疾病，弹性蛋白的降解和断裂可能导致原位轴向预拉伸减少，在肢体屈曲时容易导致更严重的动脉扭结和有效动脉功能的丧失。(C) 2014材料学报Elsevier Ltd.出版。版权所有。
Surgical and interventional therapies for peripheral artery disease (PAD) are notorious for high rates of failure. Interactions between the artery and repair materials play an important role, but comprehensive data describing the physiological and mechanical characteristics of human femoropopliteal arteries are not available. Fresh femoropopliteal arteries were obtained from 70 human subjects (13-79 years old), and in situ vs. excised arterial lengths were measured. Circumferential and longitudinal opening angles were determined for proximal superficial femoral, proximal popliteal and distal popliteal arteries. Mechanical properties were assessed by multi-ratio planar biaxial extension, and experimental data were used to calculate physiological stresses and stretches, in situ axial force and anisotropy. Verhoeff-Van Gieson-stained axial and transverse arterial sections were used for histological analysis. Most specimens demonstrated nonlinear deformations and were more compliant longitudinally than circumferentially. In situ axial pre-stretch decreased 0.088 per decade of life. In situ axial force and axial stress also decreased with age, but circumferential physiological stress remained constant. Physiological circumferential stretch decreased 55-75% after 45 years of age. Histology demonstrated a thickened external elastic lamina with longitudinally oriented elastin that was denser in smaller, younger arteries. Axial elastin likely regulates axial pre-stretch to help accommodate the complex deformations required of the artery wall during locomotion. Degradation and fragmentation of elastin as a consequence of age, cyclic mechanical stress and atherosclerotic arterial disease may contribute to decreased in situ axial pre-stretch, predisposing to more severe kinking of the artery during limb flexion and loss of energy-efficient arterial function. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.