Epidemiology of cleft palate alone and cleft palate with accompanying defects
Epidemiology of cleft palate alone and cleft palate with accompanying defects
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DOI：
10.1007/s10654-007-9129-y
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发表时间：
2007-06-01
影响因子：
13.6
通讯作者：
Vindenes, Hallvard
中科院分区：
文献类型：
--
作者：
Harville, Emily W.;Wilcox, Allen J.;Vindenes, Hallvard
腭裂合并多种畸形的流行病学通常被认为与单纯的腭裂不同，但关于这一问题的实证数据很少。我们在一个基于人口的数据集中探索了这一点，该数据集结合了两个来源的数据：挪威出生登记处1967年至1998年记录的180万名活产婴儿，以及挪威两个修复腭裂的手术中心。两种来源中的任何一种都能鉴定出伴随缺陷。采用分层分析和Logistic回归分析进行协变量的相对危险度评估。在1431名患有腭裂的婴儿中，31%的婴儿有一个或两个来源记录的另一种出生缺陷。随着时间的推移，单纯性腭裂的患病率是稳定的，而伴有其他缺陷的腭裂的患病率显著增加。女孩患单纯性腭裂的风险较高(相对风险为1.4；95%可信区间为1.2-1.6)，但不存在腭裂合并其他畸形的风险(1.1；0.88-1.3)。年龄较大的父母和是近亲的父母没有增加患孤立性腭裂的风险，但生下患有腭裂并伴有其他缺陷的婴儿的可能性是其他人的两倍。伴有和不伴有畸形的腭裂患者的危险因素不同。
The epidemiology of cleft palate with multiple defects is often thought to be different from that of cleft palate alone, but there are few empirical data on this question. We explored this in a population-based data set created by combining data from two sources: the 1.8 million live births recorded from 1967 to 1998 in the Norwegian Birth Registry, and the two Norwegian surgical centers that repair cleft palate. Accompanying defects were identified from either source. Stratified analysis and logistic regression were used to assess relative risks by covariates. Of 1,431 babies with cleft palate, 31 % had another birth defect recorded by one or both sources. Prevalence of isolated cleft palate was steady over time, while cleft palate with other defects increased substantially. Girls had a higher risk of isolated cleft palate (relative risk 1.4; 95% confidence interval, 1.2-1.6) but not of cleft palate accompanied by other defects (1.1; 0.88-1.3). Older parents and parents who were first cousins had no increased risk of isolated cleft palate, but were twice as likely as others to have a baby with cleft palate accompanied by other defects. Risk factors differ between cases of cleft palate with and without accompanying defects.