Anxiety and Depression in People with Eczema or Psoriasis: A Comparison of Associations in UK Biobank and Linked Primary Care Data.
Anxiety and Depression in People with Eczema or Psoriasis: A Comparison of Associations in UK Biobank and Linked Primary Care Data.
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DOI：
10.2147/clep.s417176
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发表时间：
2023
影响因子：
3.9
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中科院分区：
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之前的研究表明，湿疹和牛皮癣以及焦虑和抑郁之间存在关联。我们调查了抑郁症和焦虑症在不同确定环境下的相关性是否一致，包括来自英国生物库(2006-2010年间招募年龄在40-69岁之间的大型纵向队列)的采访和调查回复，以及将初级保健数据联系起来，目的是通过三角测量得出更可靠的结论。在横断面研究中，我们估计了湿疹或牛皮癣与焦虑或抑郁之间的关系，将焦虑或抑郁定义为1)在英国生物库招募面试中自我报告的先前诊断；2)从2016年英国生物库心理健康跟踪调查中获得的PHQ-9/GAD-7得分表明抑郁或焦虑；以及3)在相关初级保健电子健康记录数据中的诊断。我们分析了230,047人的生物库和初级保健数据。我们发现湿疹、牛皮癣、焦虑和抑郁的数据来源之间的一致性很差。例如，9474人在初级保健数据中被诊断为湿疹，4069人在英国生物库访谈中自我报告曾被诊断为湿疹，1536人在两个数据来源中都有湿疹(抑郁症分别为40,455；13,320；和9588)。患有湿疹或牛皮癣(在初级保健或基线访谈中记录)与焦虑和抑郁的几率更高相关。例如，1)招募面试(1.36，95%可信区间1.27-1.45)；2)跟踪调查(1.24，1.09-1.39)；3)初级保健记录(1.56，1.50-1.62)。我们的发现支持牛皮癣和湿疹患者中精神疾病患病率的增加，这在精神卫生服务的规划中应该得到考虑。然而，我们发现在环境之间的疾病确定方面的一致性很差，这对电子健康记录中的数据解释有影响。
Previous research has shown associations between eczema and psoriasis and anxiety and depression. We investigated whether associations are consistent across different settings of ascertainment for depression and anxiety, including interview and survey responses from UK Biobank (a large longitudinal cohort recruiting individuals aged 40–69 years between 2006–2010), and linked primary care data, with the aim of drawing more reliable conclusions through triangulation. In cross-sectional studies, we estimated associations between eczema or psoriasis and anxiety or depression, defining anxiety or depression as 1) self-reported previous diagnosis at UK Biobank recruitment interview; 2) PHQ-9/GAD-7 score indicating depression or anxiety from a UK Biobank mental health follow-up survey in 2016; and 3) diagnosis in linked primary care electronic health record data. We analysed 230,047 people with linked Biobank and primary care data. We found poor agreement between the data sources for eczema, psoriasis, anxiety, and depression. Eg, 9474 had a previous eczema diagnosis in primary care data, 4069 self-reported previous eczema diagnosis at the UK biobank interview, and 1536 had eczema in both data sources (for depression 40,455; 13,320; and 9588 respectively). Having eczema or psoriasis (recorded in primary care or baseline interview) was associated with higher odds of anxiety and depression. Eg, the adjusted odds ratio for depression comparing those with eczema to those without was greater than 1 when defining the outcome from 1) the recruitment interview (1.36, 95% confidence interval 1.27–1.45); 2) the follow-up survey (1.24, 1.09–1.39), and 3) primary care records (1.56, 1.50–1.62). Our findings support increased prevalence of mental illness in people with psoriasis and eczema across multiple data sources, which should be considered in planning of mental health services. However, we found poor agreement in disease ascertainment between settings, with implications for data interpretation in electronic health records.