Epidemiology and outcomes of acute lung injury
Epidemiology and outcomes of acute lung injury
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DOI：
10.1378/chest.06-1976
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发表时间：
2007-02-01
期刊：
影响因子：
9.6
通讯作者：
Herridge, Margaret S.
中科院分区：
文献类型：
--
作者：
Rubenfeld, Gordon D.;Herridge, Margaret S.
急性肺损伤（ALI）及其表现为更严重的低氧血症，ARDS，是一个具有挑战性的实体的临床研究，因为，像许多危重病综合征，它缺乏一个公认的诊断测试，并依赖于一系列的临床结果进行诊断。尽管存在这些障碍，但在ALI的临床和人群流行病学方面仍取得了重要进展。本文将综述近年来关于ALI的发病率、诊断、病因学和预后因素、相关疾病亚群、死亡率和长期预后的研究。详细了解ALI的流行病学和预后对未来研究急性表现和长期后遗症的机制至关重要。设计研究以确定发展ALI的遗传风险因素，并制定治疗或预防幸存者发病的策略。
Acute lung injury (ALI) and its presentation with more severe hypoxemia, the ARDS, is a challenging entity for clinical investigation because, like many critical illness syndromes, it lacks an accepted diagnostic test and relies on a constellation of clinical findings for diagnosis. Despite these barriers, there have been important advances in the clinical and population epidemiology of ALI This article will review recent studies of the incidence, diagnosis, etiologic and prognostic factors, relevant disease subsets, mortality, and long-term outcomes of ALI A detailed understanding of the epidemiology and outcomes of ALI is essential for future research on mechanisms of both the acute presentation and long-term sequelae, for designing studies to identify genetic risk factors for developing ALI, and to develop strategies to treat or prevent the morbidity encountered by survivors.