Association of alkaline-phosphatase-positive reticulum cells in bone marrow with granulocytic precursors.
Association of alkaline-phosphatase-positive reticulum cells in bone marrow with granulocytic precursors.
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DOI：
10.1084/jem.150.4.919
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发表时间：
1979-10-01
期刊：
影响因子：
--
通讯作者：
Bainton DF
中科院分区：
文献类型：
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作者：
Westen H;Bainton DF
在骨髓中，一个复杂的基质形成了造血微环境的结构基础。在本研究中，利用光镜和电镜组织化学，在大鼠和小鼠的完整骨髓组织切片上确定了两种不同类型的基质细胞：(a)成纤维细胞类型的网状细胞，其特征是与其质膜相关的碱性磷酸酶。我们把这种细胞称为碱性磷酸酶阳性网状细胞（Al-RC）。它与粒细胞前体，特别是成髓细胞和嗜中性早幼粒细胞密切相关。这些网状细胞遍布骨髓，但主要集中在内皮附近。(b)一种巨噬细胞型网状细胞，其特征是溶酶体酸性磷酸酶丰富，主要与红系前体相关（其他人也观察到）。与上述细胞类型相反，后一种细胞在整个骨髓中均匀分布。我们推测Al-RC是骨髓中粒细胞分化所必需的间充质间质细胞。
In the bone marrow, an elaborate stroma forms the structural basis of the hemopoietic microenvironment. In this study, two different types of stromal cells were identified with certainty on tissue sections of intact bone marrow of rats and mice using light and electron microscopic histochemistry: (a) a fibroblast-type of reticulum cell which is characterized by having alkaline phosphatase associated with its plasma membrane. We refer to this cell as the alkaline-phosphatase- positive reticulum cell (Al-RC). It is closely associated with granulocytic precursors, particularly myeloblasts and neutrophilic promyelocytes. These reticulum cells may be found throughout the marrow but are concentrated near the endosteum. (b) a macrophage-type of reticulum cell which is characterized by its abundance of lysosomal acid phosphatase and is mainly associated with erythroid precursors (as observed by others). In contrast to the above-mentioned cell type, this latter cell was found to be distributed uniformly throughout the marrow. We speculate that the Al-RC are mesenchymal stromal cells necessary for granulocytic differentiation in bone marrow.