Effects of gold compounds on the function of phagocytic cells. I. Suppression of phagocytosis and the generation of chemiluminescence by polymorphonuclear leukocytes.
Effects of gold compounds on the function of phagocytic cells. I. Suppression of phagocytosis and the generation of chemiluminescence by polymorphonuclear leukocytes.
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金化合物对吞噬细胞功能的影响。
DOI：
10.1002/art.1780260114
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发表时间：
1982
影响因子：
--
通讯作者：
Ken Wong
中科院分区：
文献类型：
--
作者：
Paul Davis;Carol Johnston;Miller Cl;Ken Wong
使用白色念珠菌吞噬方法和活化细胞化学发光的产生来评估金硫苹果酸钠（GSTM）和金诺芬（AF）对多形核（PMN）白细胞的影响。这两种化合物抑制白念珠菌的吞噬作用，但在治疗浓度，这是唯一一致的和显着的AF。这种药物，但不是GSTM，也有抑制作用的化学发光的产生。这些结果表明AF对PMN功能的影响比GSTM更强。他们还表明，这些化合物在体外的效果可能彼此不同，并与以前报道的其他吞噬细胞，特别是外周血单核细胞的效果不同。
The effect of sodium aurothiomalate (GSTM) and auranofin (AF) on polymorphonuclear (PMN) leukocytes has been assessed using a Candida albicans phagocytosis method and by the generation of chemiluminescence of activated cells. Both compounds inhibited the phagocytosis of Candida albicans but at therapeutic concentrations this was only consistent and significant with AF. This drug, but not GSTM, also had a suppressive effect on the generation of chemiluminescence. These results suggest that AF has a more potent effect on PMN function than GSTM. They also suggest that the effect of these compounds in vitro may differ from each other and from the effects previously reported with other phagocytic cells, notably peripheral blood mononuclear cells.