Penicillamine-induced rapidly progressive glomerulonephritis in patients with progressive systemic sclerosis: successful treatment of two patients and a review of the literature.
Penicillamine-induced rapidly progressive glomerulonephritis in patients with progressive systemic sclerosis: successful treatment of two patients and a review of the literature.
复制标题
进行性系统性硬化症患者青霉胺诱发的快速进展性肾小球肾炎：两名患者的成功治疗和文献综述。
DOI：
10.1016/s0272-6386(86)80019-1
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Neilson,EG
中科院分区：
文献类型：
--
作者：
Ntoso,KA;Tomaszewski,JE;Jimenez,SA;Neilson,EG
虽然D-青霉胺已被有效地用于治疗多种疾病，如胱氨酸尿症、威尔逊病、类风湿性关节炎和进行性系统性硬化症，但在长期使用该药物时观察到了几种毒性药物反应。最严重的副作用之一是使用数月后发生的肾脏变化。我们现在报告两例硬皮病患者在D-青霉胺治疗期间出现狼疮和新月体肾小球肾炎的血清学证据。两名患者均对甲基强的松龙脉冲治疗和随后的每日类固醇治疗有反应。我们还审查了目前的各种青霉胺肾病的信息。
Although D-penicillamine has been used effectively in the management of a variety of diseases such as cystinuria, Wilson's disease, rheumatoid arthritis, and progressive systemic sclerosis, several toxic drug reactions have been observed with prolonged administration of this agent. One of the most serious side effects is the renal changes that occur following several months of use. We now report two patients with scleroderma who developed serologic evidence of lupus and crescentic glomerulonephritis during treatment with D-penicillamine. Both patients responded to pulse methylprednisolone and subsequent daily steroids. We also review the current information available on the variety of penicillamine nephropathies.