Lipid composition of human neural tumors.
Lipid composition of human neural tumors.
复制标题
人类神经肿瘤的脂质成分。
作者：
A. Yates;D. Thompson;C. Boesel;C. Albrightson;R. Hart
测定了11例人神经肿瘤组织和2例神经胶质瘤细胞的神经节苷、胆固醇和磷脂含量。所有肿瘤组织的水浓度均高于人灰质或白质，但总脂质浓度低于人灰质或白质。一般来说，它们含有较少的胆固醇、鞘磷脂和丝氨酸甘油磷脂，但比白质含有较多的胆碱甘油磷脂。总神经节苷脂唾液酸的浓度介于灰质和白质之间。与正常大脑相比，所有肿瘤中结构较不复杂的神经节苷脂的比例都较大，而结构较复杂的神经节苷脂的比例则较小。这在快速生长的肿瘤中最为明显，而分化较好的星形细胞瘤含有最大比例的复杂神经节苷。培养肿瘤细胞的总脂质和总磷脂含量与其亲本组织相似。然而，培养物的胆固醇、鞘磷脂和总神经节苷比它们的母体组织少。在培养物和亲本组织中均有大量的胆碱和乙醇胺浆磷脂。两种培养物的神经节苷脂模式都很复杂，但它们比它们的亲本组织含有更大比例的结构简单的神经节苷脂。——耶茨，A. J.， D. K.汤普森，C. P.博塞尔，C.奥尔布赖特森，R. W.哈特人神经肿瘤的脂质组成。
Gangliosides, cholesterol, and phospholipids were quantitated in the tissues of 11 human neural tumors and the cells of two gliomas cultured in vitro. All tumor tissues contained higher water concentrations but lower total lipid concentrations than either human grey or white matter. In general they contained less cholesterol, sphingomyelin, and serine glycerophospholipid but more choline glycerophospholipid than white matter. Concentrations of total ganglioside sialic acid were intermediate between grey and white matter. Compared with normal brain, all tumors had greater proportions of the structurally less complex gangliosides and smaller proportions of the more complex gangliosides. This was most marked in the rapidly growing tumors while the better differentiated astrocytomas contained the greatest proportions of complex gangliosides. The cells of the cultured tumors contained amounts of total lipid and total phospholipid similar to their parent tissues. However, the cultures had less cholesterol, sphingomyelin, and total ganglioside than their parent tissues. There were significant amounts of choline and ethanolamine plasmalogens in both cultures and parent tissues. The ganglioside patterns of both cultures were complex but they contained a greater proportion of structurally simpler gangliosides than their parent tissues.-Yates, A. J., D. K. Thompson, C. P. Boesel, C. Albrightson, and R. W. Hart. Lipid composition of human neural tumors.