CENTROSOME AND KINETOCHORE MOVEMENT DURING MITOSIS
CENTROSOME AND KINETOCHORE MOVEMENT DURING MITOSIS
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DOI：
10.1016/0955-0674(94)90114-7
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发表时间：
1994-02-01
影响因子：
7.5
通讯作者：
RIEDER, CL
中科院分区：
文献类型：
--
作者：
AULT, JG;RIEDER, CL
在过去的一年里，我们在有丝分裂过程中染色体如何均匀分布到子细胞的理解上取得了重要进展。与硅藻和酵母中的情况不同，现在看来，在脊椎动物中，纺锤体形成和后期B期间的纺锤体极（中心体）分离主要是由星体牵引而不是推动机制介导的。动粒运动是方向不稳定的，这对染色体如何移动到形成纺锤体的赤道具有重要影响。最后，观察到即使在高水平的成熟促进因子存在下也会发生姐妹染色单体分离，这表明导致这种现象的一系列生化事件不是细胞退出有丝分裂途径的必要部分。
During the past year important progress has been made in refining our understanding of how chromosomes become equally distributed to daughter cells during mitosis. Unlike the situation in diatoms and yeast, it now appears that spindle pole (centrosome) separation during spindle formation and anaphase B is mediated in vertebrates primarily by an astral pulling, and not a pushing, mechanism. Kinetochore motility is directionally unstable, which has important consequences for how chromosomes move to the equator of the forming spindle. Finally, the observation that sister chromatid disjunction occurs even in the presence of high levels of maturation promoting factor reveals that the series of biochemical events responsible for this phenomenon is not an obligatory part of the pathway by which the cell exits mitosis.