Nuclear bodies in the Drosophila germinal vesicle
Nuclear bodies in the Drosophila germinal vesicle
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DOI：
10.1007/s10577-006-1062-5
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发表时间：
2006-05-01
影响因子：
2.6
通讯作者：
Gall, Joseph G.
中科院分区：
文献类型：
--
作者：
Liu, Ji-Long;Buszczak, Michael;Gall, Joseph G.
果蝇卵母细胞的萌发囊泡在第一次减数分裂前期的后半部分处于转录静止状态。伴随着基因组的沉默，核仁在早期消失，染色质浓缩成一个紧凑的物质，称为核小体。一个突出的Cajal体（内体）存在于大部分的前期，附着在核小体上。U7小核（sn）RNP的组分存在于一个单独的体中，即组蛋白基因座体，它也附着在核小体上。组蛋白基因座体在卵子发生的第5阶段后不再能用U7 snRNP探针检测到。其他几种性质未知的核体可以通过相差、微分干涉差和电子显微镜来检测。
The germinal vesicle of the Drosophila oocyte is transcriptionally quiescent during the latter part of the first meiotic prophase. Concomitant with silencing of the genome, the nucleolus disappears at an early stage and the chromatin condenses into a compact mass called the karyosome. A prominent Cajal body (endobody) is present during most of prophase, attached to the karyosome. Components of the U7 small nuclear (sn) RNP reside in a separate body, the histone locus body, which is also attached to the karyosome. The histone locus body is no longer detectable with probes for the U7 snRNP after about stage 5 of oogenesis. Several other nuclear bodies of unknown nature can be detected by phase contrast, differential interference contrast, and electron microscopy.