A THEORY OF SITE DISTRIBUTION OF MELANOMAS - QUEENSLAND, AUSTRALIA
A THEORY OF SITE DISTRIBUTION OF MELANOMAS - QUEENSLAND, AUSTRALIA
复制标题
DOI：
10.1007/bf00052747
复制
发表时间：
1992-11-01
影响因子：
2.3
通讯作者：
GREEN, A
中科院分区：
文献类型：
--
作者：
GREEN, A
虽然阳光照射被认为与皮肤黑色素瘤有因果关系，但在阳光照射较少的区域（如背部）以及长期暴露的部位（如面部）的高发病率表明，与阳光的关联不如其他皮肤癌直接。为了解释这种神秘的网站分布，黑素细胞恶性转化的网站依赖性易感性的理论提出。作为可能的证据，对澳大利亚昆士兰州一年内诊断出的所有黑色素瘤进行了调查，以寻找邻近黑色素瘤的良性黑色素细胞痣细胞的组织学证据，并根据解剖分布进行分析。结果表明，区域性变化的比例与邻近痣的黑色素瘤不能解释区域性变化的痣密度，这表明有不同的敏感性痣恶变。考虑到痣细胞等同于黑素细胞，这一发现将支持这样的假设，即根据解剖部位，大的黑素细胞对阳光的促有丝分裂刺激具有不同的反应。
Although sun exposure is believed to be associated causally with cutaneous melanoma, the high incidence on less sun-exposed areas such as the back, as well as on chronically exposed sites such as the face, suggests that the association with sunlight is less straightforward than for other skin cancers. To explain this enigmatic site distribution, a theory of site-dependent susceptibility of melanocytes to malignant transformation is proposed. As possible evidence, all melanomas diagnosed in the state of Queensland, Australia, over a one-year period were surveyed for histologic evidence of benign melanocytic nevus cells adjacent to the melanoma, and analyzed according to anatomic distribution. Results showed a regional variation in the proportion of melanomas with adjacent nevi not explicable by regional variation in nevus density, which suggests that there is a varying susceptibility of nevi to malignant change. Given that nevus cells are equivalent to melanocytes, this finding would support the hypothesis that melanocytes at-large have a differential response to the mitogenic stimulus of sunlight according to anatomic site.