Efficacy and Safety of Dual-Opioid Therapy in Acute Pain
Efficacy and Safety of Dual-Opioid Therapy in Acute Pain
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DOI：
10.1111/j.1526-4637.2012.01330.x
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发表时间：
2012-03-01
期刊：
影响因子：
3.1
通讯作者：
Webster, Lynn
中科院分区：
文献类型：
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作者：
Webster, Lynn
背景尽管阿片类药物被广泛接受为治疗急性术后疼痛的标准疗法，但不良事件（AE）的频繁发生以及患者的巨大负担和护理成本是最佳剂量和坚持处方治疗的障碍。由于对两种阿片类药物联合给药的潜在获益缺乏了解，以及对副作用的潜在担忧和对额外获益的怀疑，因此通常不推荐将两种阿片类药物联合给药作为中重度急性疼痛的多模式治疗选择。两种或多种阿片类药物联合给药的研究结果证明了协同镇痛作用，阿片类药物相关AE的发生率相似或较低。吗啡和羟考酮就是其中一种。
Background. Although opioids are widely accepted as standard therapy for treating acute postoperative pain, the frequent occurrence of adverse events (AEs) and the substantial burden on the patient and the costs of care are a barrier to optimal dosing and adherence to prescribed treatment. Coadministration of two opioids is not often recommended as a multimodal treatment option for moderate to severe acute pain because of lack of knowledge about the potential benefit of such combinations and due to potential concerns about side effects and doubts about the added benefits. Study results on the coadministration of two or more opioids demonstrate synergistic analgesia with a similar or lower incidence of opioid-related AEs. One such combination is morphine and oxycodone.