Primacy of beta-cell dysfunction in the development of hyperglycemia: a study in the Japanese general population.
Primacy of beta-cell dysfunction in the development of hyperglycemia: a study in the Japanese general population.
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DOI：
10.1016/j.metabol.2004.02.024
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发表时间：
2004-07
期刊：
影响因子：
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通讯作者：
M. Katakura;M. Komatsu;Yoshihiko Sato;K. Hashizume;T. Aizawa
中科院分区：
文献类型：
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作者：
M. Katakura;M. Komatsu;Yoshihiko Sato;K. Hashizume;T. Aizawa
为了阐明糖耐量异常在普通人群中的演变规律，对504名日本健康体检者(男/女：347/157)的血糖(PG)、β细胞功能(胰岛素原指数[II]=ΔIRI0-30/ΔPG0-30on 75g口服葡萄糖耐量试验[IRI]为免疫反应性胰岛素)、胰岛素敏感性(SI；由定量胰岛素敏感性检查指数[Quicki]确定)、年龄和体重指数之间的关系进行了分析。平均(±SD)年龄53(±11)岁，体重指数23·6(±3·2)kg/m2，空腹血糖5·61(±0·97)−/L，2小时血糖7·42(±3·1)mmol/L，II 74·2(±169.3)[pmol/L]·[μ/L]−1，Quicki 0.385(±0.057)[Log(Log(Log)U/mL)+Log(mg/100mL)]Log 1。高空腹血糖和2 h PG分别与低II独立相关，快速度低、年龄大、BMI高；经多元线性回归分析，空腹血糖=8.565−1.201·log[II]−5.374·QUICI+0.007·AGE+0.030·BMI(R2=0.442)，2小时PG=14.239−4.206·LOG[II]−0.141·QUICI+0.034−AGE+0.141.BMI(R2=0.141.BMI)。因此，PG的升高与β细胞功能障碍的相关性最显著，而与Si降低、年龄增大和体重指数的相关性不显著(尤其是在PG 2小时的情况下)。总而言之，在日本普通人群中，β细胞功能障碍在发展为糖耐量异常的过程中占主导地位。
To elucidate the hierarchy in the evolution of glucose intolerance in the general population, the relationship between plasma glucose (PG), β-cell function (insulinogenic index [II] = ΔIRI0–30/ΔPG0–30on 75 g oral glucose tolerance test [OGTT], where IRI is immunoreactive insulin), insulin sensitivity (Si; determined by quantitative insulin sensitivity check index [QUICKI]), age, and body mass index (BMI) were analyzed in 504 Japanese health examinees (men/women: 347/157). The mean (±SD) age was 53 (±11) years, BMI 23.6 (±3.2) kg/m2, fasting PG (FPG) 5.61 (±0.97) mmol/L, 2-hour PG 7.42 (±3.1) mmol/L, II 74.2 (±169.3) [pmol/L] · [mmol/l]−1, and QUICKI 0.385 (±0.057) [log (μU/mL) + log (mg/100 mL)]−1. Higher FPG and 2-hour PG, respectively, were independently correlated with lower II, lower QUICKI, higher age, and higher BMI; the standardized correlation coefficient was largest for the correlation between PG and II. Based on the multiple linear regression, FPG = 8.565 − 1.201 · log [II] − 5.374 · QUICKI + 0.007 · age + 0.030 · BMI (r2= 0.442), and 2-hour PG = 14.239 − 4.206 · log [II] − 0.141 · QUICKI + 0.034 − age + 0.141 · BMI (r2= 0.493). Thus, elevation of PG correlated most prominently with β-cell dysfunction and less prominently with decreased Si, higher age, and BMI (especially so in the case of 2-hour PG). In conclusion, the primacy of β-cell dysfunction in the process of developing glucose intolerance was strongly suggested in the Japanese general population.