Cognitive performance among the elderly and dietary fish intake: the Hordaland Health Study
Cognitive performance among the elderly and dietary fish intake: the Hordaland Health Study
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DOI：
10.1093/ajcn/86.5.1470
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发表时间：
2007-11-01
影响因子：
7.1
通讯作者：
Smith, A. David
中科院分区：
文献类型：
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作者：
Nurk, Eha;Drevon, Christian A.;Smith, A. David
背景：越来越多的证据表明，老年受试者的认知障碍和痴呆症可能会受到包括海鲜在内的饮食的影响。目的：目的是检查摄入不同量的各种海鲜（鱼和鱼制品）与认知表现之间的横截面关系。设计：受试者（n = 2031 名受试者，55% 女性），年龄 70-74 岁，从挪威西部的普通人群中招募并接受认知测试。认知测试组包括肯德里克对象学习测试、轨迹制作测试（A 部分）、数字符号测试的修改版本、块设计、迷你精神状态检查和受控口语联想测试。认知表现不佳被定义为跟踪测试的最高十分分和所有其他测试的最低十分分。结果：鱼和鱼制品每日平均摄入量 >= 10 克/天的受试者 (n = 195 1) 与摄入量 < 10 克/天的受试者 (n = 80) 相比，平均测试分数明显更高，认知表现不佳的发生率较低。海鲜总摄入量与认知能力之间的关联具有很强的剂量依赖性。当摄入量约为 75 克/天时观察到最大效果。大多数认知功能都受到鱼类摄入量的影响。对于未加工的瘦鱼和多脂鱼，这种影响更为明显。结论：在老年人中，富含鱼和鱼制品的饮食与更好的认知能力相关，且呈剂量依赖性。
Background: Increasing evidence suggests that cognitive impairment and dementia in older subjects might be influenced by a diet including seafood.Objective: The objective was to examine the cross-sectional relation between intake of different amounts of various seafood (fish and fish products) and cognitive performance.Design: The subjects (n = 2031 subjects, 55% women), aged 70-74 y, were recruited from the general population in Western Norway and underwent cognitive testing. A cognitive test battery included the Kendrick Object Learning Test, Trail Making Test (part A), modified versions of the Digit Symbol Test, Block Design, Mini-Mental State Examination, and Controlled Oral Word Association Test. Poor cognitive performance was defined as a score in the highest decile for the Trail Making Test and in the lowest decile for all other tests.Results: Subjects whose mean daily intake of fish and fish products was >= 10 g/d (n = 195 1) had significantly better mean test scores and a lower prevalence of poor cognitive performance than did those whose intake was < 10 g/d (n = 80). The associations between total intake of seafood and cognition were strongly dose-dependent; the maximum effect was observed at an intake of approximate to 75 g/d. Most cognitive functions were influenced by fish intake. The effect was more pronounced for nonprocessed lean fish and fatty fish.Conclusions: In the elderly, a diet high in fish and fish products is associated with better cognitive performance in a dose-dependent manner.