Getting under the Skin: The Immunopathogenesis of Streptococcus pyogenes Deep Tissue Infections
Getting under the Skin: The Immunopathogenesis of Streptococcus pyogenes Deep Tissue Infections
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DOI：
10.1086/653116
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发表时间：
2010-07-01
影响因子：
11.8
通讯作者：
Norrby-Teglund, Anna
中科院分区：
文献类型：
--
作者：
Johansson, Linda;Thulin, Pontus;Norrby-Teglund, Anna
化脓性链球菌可在免疫功能正常的个体中引起多种疾病，从咽扁桃体炎到危及生命的侵袭性疾病，如链球菌中毒性休克综合征，以及快速进展的深部组织感染，如坏死性筋膜炎。坏死性筋膜炎经常与链球菌中毒性休克综合征合并出现，这进一步增加了发病率和死亡率。我们在此回顾组织环境中宿主与病原体的相互作用，并讨论使用静脉注射免疫球蛋白作为这些危及生命的感染的潜在辅助治疗。
Streptococcus pyogenes can cause a variety of diseases in immunocompetent individuals, from pharyngotonsillitis to life-threatening invasive diseases, such as streptococcal toxic shock syndrome, and rapidly progressing deep-tissue infections, such as necrotizing fasciitis. Necrotizing fasciitis is often seen in combination with streptococcal toxic shock syndrome, which further increases morbidity and mortality. We review here the host-pathogen interactions in the tissue milieu and discuss the use of intravenous immunoglobulin as potential adjunctive therapy in these life-threatening infections.