THE RELATIONSHIP OF HYPERALGESIA IN SART (REPEATED COLD) STRESSED ANIMALS TO THE AUTONOMIC NERVOUS-SYSTEM
THE RELATIONSHIP OF HYPERALGESIA IN SART (REPEATED COLD) STRESSED ANIMALS TO THE AUTONOMIC NERVOUS-SYSTEM
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DOI：
10.1111/j.1474-8673.1988.tb00168.x
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发表时间：
1988-03-01
期刊：
影响因子：
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通讯作者：
KAWABATA, A
中科院分区：
文献类型：
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作者：
HATA, T;KITA, T;KAWABATA, A
1 研究了在 SART（反复冷）应激动物（小鼠和大鼠）中观察到的痛觉过敏机制与自主神经系统的关系。 2 SART 应激降低了迷走神经切断小鼠之前升高的伤害感受阈值，但未能改变交感神经切除小鼠之前降低的阈值。 3 先前在 SART 应激小鼠中降低的伤害感受阈值因迷走神经切断术而升高，但通过交感神经切除术进一步降低。 4 下丘脑腹内侧 (VMH)、下丘脑前部 (AH) 或后部 (PH) 损伤可防止 SART 应激引起的大鼠伤害性阈值降低，但下丘脑外侧 (LH) 损伤则无此作用。 5 应激大鼠先前降低的伤害感受阈值并未因 VMH、AH 或 PH 损伤而改变，但因 LH 损伤而升高。 6 上述研究结果表明，SART 应激动物的痛觉过敏显然与副交感神经系统关系不大，但与交感神经系统张力降低的关系相对较大。
1 The mechanism of hyperalgesia observed in SART (repeated cold)-stressed animals (mice and rats) was studied in relation to the autonomic nervous system. 2 SART stress reduced the nociceptive threshold previously increased in vagotomized mice, but failed to change the threshold previously decreased in sympathectomized mice. 3 The nociceptive threshold previously decreased in SART-stressed mice was elevated by vagotomy, but decreased still more by sympathectomy. 4 Lesion of ventromedial (VMH), anterior (AH) or posterior hypothalamus (PH) prevented decrease in the nociceptive threshold of rats by SART stress, but lesion of the lateral hypothalamus (LH) had no such effect. 5 The nociceptive threshold previously decreased in stressed rats did not change by VMH, AH or PH lesion, but increased by LH lesion. 6 The above findings indicate that hyperalgesia in SART-stressed animals apparently bears little relation to the parasympathetic nervous system, but is associated relatively more with reduced tone in the sympathetic nervous system.