Altered spatial learning and delay discounting in a rat model of human third trimester binge ethanol exposure
Altered spatial learning and delay discounting in a rat model of human third trimester binge ethanol exposure
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DOI：
10.1097/fbp.0b013e32834eb07d
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发表时间：
2012-02-01
影响因子：
1.6
通讯作者：
Bizon, Jennifer L.
中科院分区：
文献类型：
--
作者：
Banuelos, Cristina;Gilbert, Ryan J.;Bizon, Jennifer L.
围产期发育期间接触乙醇会导致认知异常，包括学习、注意力和记忆困难以及冲动性增强。本研究的目的是评估在人类妊娠晚期等效大脑发育过程中接受暴饮乙醇暴露胃插管模型的大鼠在空间学习和冲动选择任务中的表现。雄性和雌性 Sprague-Dawley 幼鼠在出生后第 4-9 天用乙醇（5.25 g/kg/天）插管。在青春期（出生后 35-38 天），这些大鼠和假插管的同窝对照大鼠在空间和提示版本的莫里斯水迷宫中接受训练。随后对一部分雄性大鼠进行了延迟折扣任务测试，以评估冲动选择。与对照组相比，暴露于乙醇的大鼠在空间上受到损害，但在水迷宫的提示版本上表现与对照组相当。暴露于乙醇的大鼠在延迟贴现任务中也表现出对大延迟奖励的更大偏好，但没有证据表明奖励敏感性或持续行为发生改变。这些数据表明，产后早期间歇性暴饮暴食乙醇暴露对认知具有长期、有害但选择性的影响，这表明即使在人类妊娠后期相对短暂的乙醇暴露也可能对认知功能有害。行为药理学 23:54-65 (C) 2012 Wolters Kluwer Health |利平科特·威廉姆斯和威尔金斯。
Ethanol exposure during perinatal development can cause cognitive abnormalities including difficulties in learning, attention, and memory, as well as heightened impulsivity. The purpose of this study was to assess performance in spatial learning and impulsive choice tasks in rats subjected to an intragastric intubation model of binge ethanol exposure during human third trimester-equivalent brain development. Male and female Sprague-Dawley rat pups were intubated with ethanol (5.25 g/kg/day) on postnatal days 4-9. At adolescence (between postnatal days 35-38), these rats and sham intubated within-litter controls were trained in both spatial and cued versions of the Morris water maze. A subset of the male rats was subsequently tested on a delay-discounting task to assess impulsive choice. Ethanol-exposed rats were spatially impaired relative to controls, but performed comparably to controls on the cued version of the water maze. Ethanol-exposed rats also showed greater preference for large delayed rewards on the delay discounting task, but no evidence for altered reward sensitivity or perseverative behavior. These data demonstrate that early postnatal intermittent binge-like ethanol exposure has prolonged, detrimental, but selective effects on cognition, suggesting that even relatively brief ethanol exposure late in human pregnancy can be deleterious for cognitive function. Behavioural Pharmacology 23:54-65 (C) 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.