INCREASED ERYTHROPOIETIN PRODUCTION IN CHILDREN WITH SEVERE MALARIAL ANEMIA
INCREASED ERYTHROPOIETIN PRODUCTION IN CHILDREN WITH SEVERE MALARIAL ANEMIA
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DOI：
10.4269/ajtmh.1995.53.547
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发表时间：
1995-11-01
影响因子：
3.3
通讯作者：
KREMSNER, PG
中科院分区：
文献类型：
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作者：
BURCHARD, GD;RADLOFF, P;KREMSNER, PG
对加蓬84例恶性疟原虫疟疾患儿的血浆免疫反应性促红细胞生成素浓度进行了测定。血红蛋白或红细胞压积与血浆促红细胞生成素之间存在反对数/线性关系，表明促红细胞生成素水平随着循环血红蛋白降低呈指数增加。这些结果表明，恶性疟原虫疟疾不会导致促红细胞生成素产生减少，反过来，促红细胞生成素产生减少不会导致疟疾性贫血的发病机制。促红细胞生成素对恶性疟原虫疟疾患儿贫血有足够的反应。
Plasma immunoreactive erythropoietin concentrations were determined in 84 children with Plasmodium falciparum malaria in Gabon. There was an inverse log/linear relationship between hemoglobin or hematocrit and plasma erythropoietin, indicating that erythropoietin levels increased exponentially as circulating hemoglobin decreased. These results show that P. falciparum malaria does not lead to decreased erythropoietin production, and in turn reduced erythropoietin production does not contribute to the pathogenesis of malarial anemia. There is an adequate response of erythropoietin to anemia in children with P. falciparum malaria.