Report of the WHO working group on the assessment of health risks for human infants from exposure to PCDDs, PCDFs and PCBs.
Report of the WHO working group on the assessment of health risks for human infants from exposure to PCDDs, PCDFs and PCBs.
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DOI：
10.1016/s0045-6535(98)00230-6
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发表时间：
1998-10-01
期刊：
影响因子：
8.8
通讯作者：
Feeley, MM
中科院分区：
文献类型：
--
作者：
Brouwer, A;Ahlborg, UG;Feeley, MM
1995年11月20日至22日，由来自6个不同国家的12名科学代表组成的世界卫生组织工作组举行会议，重新评估围产期接触多卤芳烃（PHAHs）对婴儿的健康风险。作为其关于多氯联苯、多氯联苯和多氯联苯综合规划的一部分，在审查了以往世卫组织/欧盟磋商之后，讨论了目前的接触信息以及最近的实验和流行病学数据。过去十年的接触评估表明，在母乳样本中，多氯联苯/多氯联苯和多氯联苯的浓度持续下降，在某些国家下降幅度高达50%。新的实验数据显示，暴露于多氯联苯后，啮齿动物的多种结构、功能和行为会发生改变，而荷兰的一项多氯联苯/二恶英合作研究表明，母乳喂养的婴儿可能会出现微妙的临床、内分泌和精神/精神运动发育影响。工作组的临时结论是：1)目前的证据没有理由改变世卫组织以前关于促进/支持母乳喂养的建议；2)根据新的临床数据，支持某些观察到的实验结果的生物学合理性，应继续加强努力，以确定和控制这些污染物的环境输入来源。1998爱思唯尔科学有限公司版权所有。
On Nov. 20-22, 1995, a World Health Organization working group consisting of 12 scientific representatives from 6 different countries met to reassess the health risks to infants associated with perinatal exposure to polyhalogenated aromatic hydrocarbons (PHAHs). Following a review of previous WHO/EURO consultations, as part of their comprehensive programme on PCDDs, PCDFs and PCBs, current exposure information and recent experimental and epidemiologic data were discussed. Exposure assessments within the past decade have revealed that in the case of breast milk samples concentrations of PCDDs/DFs and PCBs have shown a continual decline, in certain countries by up to 50%. New experimental data has revealed that a variety of structural, functional and behaviourial alterations can be induced in rodent species following exposure to PHAHs while a Dutch collaborative PCB/dioxin study has illustrated subtle clinical, endocrine and mental/psychomotor development effects can occur in breast fed infants. The provisional conclusions of the working group were: 1) current evidence does not warrant altering the previous WHO recommendation for promotion/support of breast feeding and 2) based on new clinical data which supports the biological plausibility of certain observed experimental observations, continued and enhanced effort should be directed towards identifying and controlling sources of environmental input for these contaminants. (C) 1998 Elsevier Science Ltd. All rights reserved.