Proenkephalin and risk of developing chronic kidney disease: the Prevention of Renal and Vascular End-stage Disease study
Proenkephalin and risk of developing chronic kidney disease: the Prevention of Renal and Vascular End-stage Disease study
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DOI：
10.1080/1354750x.2018.1443514
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发表时间：
2018-01-01
期刊：
影响因子：
2.6
通讯作者：
Bakker, Stephan J. L.
中科院分区：
文献类型：
--
作者：
Kieneker, Lyanne M.;Hartmann, Oliver;Bakker, Stephan J. L.
背景：最近发现脑啡肽原（pro-ENK）与低估计肾小球滤过率（eGFR）相关。pro-ENK与尿白蛋白排泄（UAE）（慢性肾脏疾病（CKD）的另一个标志物）的相关性尚未研究。我们研究了前ENK与eGFR和UAE作为CKD.Methods标志物的相关性：我们纳入了4375例肾脏和血管终末期疾病预防（PREVEND）研究。结果：基线时pro-ENK的中位数为52.2（IQR：44.9-60.5）pmol/L。中位随访8.4（IQR：7.9-8.9）年后，183例受试者发生CKDeGFR，371例发生CKDUAE。Pro-ENK与CKDeGFR的相关性受性别的影响（P-交互作用
Background: Proenkephalin (pro-ENK) was recently found to be associated with low estimated glomerular filtration rate (eGFR). The association of pro-ENK with urinary albumin excretion (UAE), another marker for chronic kidney disease (CKD), has not been investigated. We examined the association of pro-ENK with eGFR and UAE as markers of CKD.Methods: We included 4375 subjects of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study. CKDeGFR was defined as development of eGFR30mg/24h.Results: Baseline median pro-ENK was 52.2 (IQR: 44.9-60.5) pmol/L. After a median follow-up of 8.4 (IQR: 7.9-8.9) years, 183 subjects developed CKDeGFR and 371 developed CKDUAE. The association of pro-ENK with CKDeGFR was modified by sex (P-interaction