Trabecular and Cortical Bone Density and Architecture in Women After 60 Days of Bed Rest Using High-Resolution pQCT: WISE 2005
Trabecular and Cortical Bone Density and Architecture in Women After 60 Days of Bed Rest Using High-Resolution pQCT: WISE 2005
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DOI：
10.1002/jbmr.482
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发表时间：
2011-10-01
影响因子：
6.2
通讯作者：
Felsenberg, Dieter
中科院分区：
文献类型：
--
作者：
Armbrecht, Gabriele;Belavy, Daniel Ludovic;Felsenberg, Dieter
长时间的卧床休息被用来模拟太空飞行的影响，并导致废用相关的骨质流失。虽然已经描述了卧床休息期间的骨密度变化，但没有关于骨微观结构变化的数据。24名25 - 40岁的健康女性参加了60天的严格6度头低位倾斜卧床休息（WISE 2005）。受试者被分配到对照组（CON，n = 8），不采取任何对策;运动组（EXE，n = 8），进行阻力和耐力训练的组合;或营养组（NUT，n = 8），接受高蛋白饮食。通过高分辨率外周定量计算机断层扫描（HR-pQCT），在基线、卧床期间和卧床后1年内测量胫骨远端和桡骨的密度和结构参数。卧床休息与所有胫骨远端密度参数的降低相关（p < 0.001），而仅桡骨远端骨小梁密度降低。胫骨远端和桡骨远端的骨小梁分离增加（p < 0.001），但这些影响在卧床休息后首次显著。桡骨远端（p = 0.021）和胫骨远端（p < 0.001）的骨小梁数量减少幅度相似。皮质厚度仅在胫骨远端减少（p < 0.001）。对抗措施对骨结构和骨密度无显著影响（p >= 0.057）。通过HR-pQCT测量，得出的结论是，女性在长期卧床期间和之后会发生骨微观结构和密度的恶化。运动和营养对策在防止这些变化方面是无效的。(C)2011年美国骨与矿物质研究学会。
Prolonged bed rest is used to simulate the effects of spaceflight and causes disuse-related loss of bone. While bone density changes during bed rest have been described, there are no data on changes in bone microstructure. Twenty-four healthy women aged 25 to 40 years participated in 60 days of strict 6-degree head-down tilt bed rest (WISE 2005). Subjects were assigned to either a control group (CON, n = 8), which performed no countermeasures; an exercise group (EXE, n = 8), which undertook a combination of resistive and endurance training; or a nutrition group (NUT, n = 8), which received a high-protein diet. Density and structural parameters of the distal tibia and radius were measured at baseline, during, and up to 1 year after bed rest by high-resolution peripheral quantitative computed tomography (HR-pQCT). Bed rest was associated with reductions in all distal tibial density parameters (p < 0.001), whereas only distal radius trabecular density decreased. Trabecular separation increased at both the distal tibia and distal radius (p < 0.001), but these effects were first significant after bed rest. Reduction in trabecular number was similar in magnitude at the distal radius (p = 0.021) and distal tibia (p < 0.001). Cortical thickness decreased at the distal tibia only (p < 0.001). There were no significant effects on bone structure or density of the countermeasures (p >= 0.057). As measured with HR-pQCT, it is concluded that deterioration in bone microstructure and density occur in women during and after prolonged bed rest. The exercise and nutrition countermeasures were ineffective in preventing these changes. (C) 2011 American Society for Bone and Mineral Research.