The potential use of mesenchymal stem cells in hematopoietic stem cell transplantation.
The potential use of mesenchymal stem cells in hematopoietic stem cell transplantation.
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DOI：
10.1038/emm.2013.2
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发表时间：
2013-01-10
影响因子：
12.8
通讯作者：
Cho, Seok-Goo
中科院分区：
文献类型：
--
作者：
Kim, Eun-Jung;Kim, Nayoun;Cho, Seok-Goo
关键词：
在过去的10年里，间充质干细胞（MSC）已经成为再生医学，癌症，自身免疫性疾病等的治疗方法，因为它们具有分化成各种组织，修复受损组织和器官的潜力，以及它们的免疫调节特性。体外和体内研究证实了MSCs的免疫调节功能，并促进了其在自身免疫性疾病和慢性炎症性疾病等临床试验中的应用。MSC在异基因造血干细胞移植（HSCT）中的作用越来越受到关注，包括造血干细胞植入和移植物抗宿主病（GVHD）的预防和治疗，并且其治疗潜力已在许多临床试验中报道。虽然MSC的临床应用的安全性是确定的，但需要进一步的修改以提高其功效。本文就骨髓间充质干细胞在造血干细胞移植中的应用作一综述。此外，我们讨论了它们在HSCT后GVHD治疗的临床试验中的应用，MSC的免疫调节能力，以及它们在HSCT领域的再生和治疗潜力。
In the last 10 years, mesenchymal stem cells (MSCs) have emerged as a therapeutic approach to regenerative medicine, cancer, autoimmune diseases, and many more due to their potential to differentiate into various tissues, to repair damaged tissues and organs, and also for their immunomodulatory properties. Findings in vitro and in vivo have demonstrated immune regulatory function of MSCs and have facilitated their application in clinical trials, such as those of autoimmune diseases and chronic inflammatory diseases. There has been an increasing interest in the role of MSCs in allogeneic hematopoietic stem cell transplantation (HSCT), including hematopoietic stem cell engraftment and the prevention and treatment of graft-versus-host disease (GVHD), and their therapeutic potential has been reported in numerous clinical trials. Although the safety of clinical application of MSCs is established, further modifications to improve their efficacy are required. In this review, we summarize advances in the potential use of MSCs in HSCT. In addition, we discuss their use in clinical trials of the treatment of GVHD following HSCT, the immunomodulatory capacity of MSCs, and their regenerative and therapeutic potential in the field of HSCT.
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DOI：
10.1073/pnas.96.15.8639
发表时间：
1999-07-20
影响因子：
11.1
作者：
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通讯作者：
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