The effect of reperfusion on neuroprotection using an inhibitor of poly(ADP-ribose) polymerase.
The effect of reperfusion on neuroprotection using an inhibitor of poly(ADP-ribose) polymerase.
复制标题
使用聚（ADP-核糖）聚合酶抑制剂进行再灌注对神经保护的影响。
DOI：
10.1097/00001756-199907130-00005
复制
发表时间：
1999
期刊：
影响因子：
1.7
通讯作者：
Greenberg,JH
中科院分区：
文献类型：
--
作者：
Takahashi,K;Greenberg,JH
THE activation of poly (ADP-ribose) polymerase (PARP) by free radical-damaged DNA plays a pivotal role in mediating ischemia-reperfusion injury. The purpose of the present study was to examine the neuroprotective effects of a PARP inhibitor, 3-aminobenzamide (3-ABA), which was administered either prior to or following reperfusion, to determine the importance of PARP inhibition prior to reperfusion. 3-ABA was injected ip either 15 min before or 15 min following reperfusion in a transient focal ischemia model in the rat. Treatment prior to the reperfusion led to a significant decrease in the volume of damaged tissue at 24 h (118.7±18.8 mm 3, mean±sd, p< 0.01), compared with the control (176.1±22.8 mm 3). However, treatment after the reperfusion failed to produce a reduction in the damaged volume (171.9±27.6 mm 3). These findings suggest that PARP activation sufficient to produce cellular damage occurs immediately after the reperfusion following cerebral ischemia.
