Synthesis, properties, and biological activity of poly[di(sodium carboxylatoethylphenoxy)phosphazene]
Synthesis, properties, and biological activity of poly[di(sodium carboxylatoethylphenoxy)phosphazene]
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DOI：
10.1021/bm050790a
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发表时间：
2006-01-01
影响因子：
6.2
通讯作者：
Chen, JP
中科院分区：
文献类型：
--
作者：
Andrianov, AK;Marin, A;Chen, JP
合成了一种新型的含羧酸酯官能团的水溶性聚磷腈共聚物--聚[二（羧乙基苯氧基钠）磷腈]（PCEP）（.）通过大分子取代反应合成。聚合物的特征在于使用H-1，P-31 NMR，和凝胶渗透色谱与多角度激光光散射检测。PCEP被证明在水溶液中进行水解降解，所示的分子量和侧基的释放减少。还制备了一系列含有不同量的残留氯原子的PCEP的不完全取代共聚物。降解速率随氯原子含量的增加而增加。体内研究表明，PCEP作为疫苗免疫佐剂的效力高。这种新型聚磷腈在水溶液中通过与生理上存在的苯胺（如精胺）发生离子络合反应而形成微球。
A new water-soluble polyphosphazene polyelectrolyte containing carboxylate functionalities, poly[di(sodium carboxylatoethylphenoxy)phosphazene] (PCEP)(.)was synthesized via reaction of macromolecular substitution. The polymer was characterized using H-1, P-31 NMR, and gel permeation chromatography with multiangle laser light scattering detection. PCEP was shown to undergo hydrolytic degradation in aqueous solutions, as indicated by the decrease in the molecular weight and the release of side groups. A series of incompletely substituted copolymers of PCEP containing varying amounts of residual chlorine atoms was also prepared. The rate of degradation for such copolymers increased with the rise in the content of chlorine atoms. In vivo studies demonstrated high potency of PCEP as a vaccine immunoadjuvant. The new polyphosphazene was also shown to be capable of forming microspheres in aqueous solutions via reactions of ionic complexation with physiologically occurring an-tines, such as spermine.