Sonographically measured adipose tissue thickness correlates with laboratory test abnormalities reflecting metabolic state in elderly women.
Sonographically measured adipose tissue thickness correlates with laboratory test abnormalities reflecting metabolic state in elderly women.
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超声测量的脂肪组织厚度与反映老年女性代谢状态的实验室测试异常相关。
DOI：
10.1089/met.2021.0082
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Watanabe T.
中科院分区：
文献类型：
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作者：
Urata T;Kishino T;Watanabe K;Shibasaki S;Yotsukura M;Mori H;Kawamura N;Tanaka T;Osaka M;Matsushima S;Yamasaki S;Ohtsuka K;Ohnishi H;Watanabe T.
背景：脂肪组织积累发展为代谢性疾病。超声是测量脂肪组织厚度的一种方便方法。本研究旨在阐明脂肪组织厚度与反映代谢异常的实验室测试值最相关的部位。方法：研究对象为37名患有代谢性疾病或基本健康的老年妇女（年龄中位数为71岁，四分位数范围为62-78岁）。测量腹部内脏脂肪组织（VAT）、皮下脂肪组织、腹膜脂肪组织、肾周脂肪组织和心外膜脂肪组织（EAT）厚度。评估实验室测试值与这些脂肪组织厚度之间的相关性。结果：在调整体重指数后，脐水平VAT厚度与甘油三酯（TGs）值（r= 0.593，P= 0.0009）和血红蛋白A1c值（r= 0.490，P= 0.0081）呈正相关，与高密度脂蛋白胆固醇值（r= - 0.521，P= 0.0045）呈负相关。EAT厚度与tg之间也存在显著正相关（r= 0.542，P= 0.0029）。结论：在超声测量的几个部位的脂肪组织厚度中，VAT厚度与代表老年妇女代谢异常的实验室测试值相关性最密切。
Background:Accumulation of adipose tissue progresses to metabolic diseases. Sonography is a convenient modality for measuring the thickness of adipose tissue. The present study aimed to clarify the site of adipose tissue thickness that correlated best with laboratory test values reflecting metabolic abnormalities.Methods:Subjects comprised 37 elderly women with metabolic diseases or an almost healthy state (median age, 71 years; interquartile range, 62–78 years). Abdominal visceral adipose tissue (VAT), subcutaneous adipose tissue, peritoneal adipose tissue, perirenal adipose tissue, and epicardial adipose tissue (EAT) thicknesses were measured. Correlations were evaluated between laboratory test values and these adipose tissue thicknesses.Results:VAT thickness measured at the level of the umbilicus correlated positively with values of triglycerides (TGs) (r= 0.593,P= 0.0009) and hemoglobin A1c (r= 0.490,P= 0.0081) and negatively with the value of high-density lipoprotein cholesterol (r= −0.521,P= 0.0045), even after adjusting for body mass index. Significant positive correlations were also found between EAT thickness and TGs (r= 0.542,P= 0.0029).Conclusions:Among the adipose tissue thicknesses measured at several sites by sonography, VAT thickness correlated most closely with laboratory test values representing metabolic abnormalities in elderly women.